头孢哌酮舒巴坦对产后盆腔腹膜炎患者的疗效及急性时相关反应蛋白影响

Effect of cefoperazonesulbactam on patientswith postpartum pelvic peritonitis and its impact on acute phase-relatedreactive protein

目的头孢哌酮舒巴坦对产后盆腔腹膜炎患者的疗效及急性时相关反应蛋白影响。方法选取2014年12月至2016年12月山东省龙口市人民医院诊治的84例产后盆腔腹膜炎患者作为研究对象。按照患者入院ID数字随机分为对照组(头孢他啶组)和观察组(头孢哌酮舒巴坦组),每组各42例。对照组患者予以头孢他啶治疗,观察组予以头孢哌酮舒巴坦治疗。比较两组患者治疗后临床疗效,比较两组患者治疗前、治疗后24h、治疗后72h的急性时相关反应蛋白水平,同时比较两组显效、有效、无效及总有效患者的发热、腹部不适感及住院时间。结果治疗后,观察组患者的临床疗效明显高于对照组,差异具有统计学意义(P<0.05);两组患者治疗前急性时相关反应蛋白水平差异无统计学意义(P>0.05),治疗24h、72h后,两组患者急性时相关反应蛋白均明显降低,差异具有统计学意义(P<0.05),且观察组患者降低更明显,差异具有统计学意义(P<0.05);观察组显效、有效、无效及总有效患者发热、腹部不适感及住院时间均明显低于对照组,差异具有统计学意义(P<0.05)。结论头孢哌酮舒巴坦对产后盆腔腹膜炎患者的临床疗效显著,可以明显降低急性时相关反应蛋白水平,明显减少治疗后发热、腹部不适感及住院时间,值得在产后盆腔腹膜炎患者治疗中推广。

Objective To study the effect of cefoperazonesulbactam on patients with postpartum pelvic peritonitis and its impact on acute phase-relatedreactive protein. Methods 84 patients with postpartum pelvic peritonitis in Longkou City People′s Hospital from December 2014 to December 2016 were selected, and according to the patient admission ID number, were randomly divided into the control group(ceftazidime group) and the observation group(cefivoxesulbactam group), 42 cases in each group. Patients in the control group were treated with ceftazidime, and the observation group was treated with cefoperazonesulbactam. The clinical efficacy in the two groups was compared. The acute phase-related protein levels were compared before treatment, 24 hours after treatment and 72 hours after treatment. The incidences of fever and abdominal discomfort and length of hospital stay were compared between patients remarkablely effective, effctive, ineffective and total effective in the two groups. Results After treatment, the clinical efficacy of the observation group was significantly higher than that of the control group, with statistically significant difference(P<0.05). There was no significant difference in the level of acute phrase-related reactive protein between the two groups before treatment(P>0.05). At 24 h and 72 h after treatment, the levels ofacute phrase-related reactive protein in the two groups were significantly decreased, with statistically significant difference(P<0.05), and more significant in the observation group, with statistically significant difference(P<0.05). The incidences of fever and abdominal discomfort and length of hospital stay of patients remarkablely effective, effctive, ineffective and total effective in the observation group were significantly lower than those of the control group, with statistically significant differences(P<0.05).Conclusions Cefoperazonesulbactam has a significant clinical effect on patients with postpartum pelvic peritonitis, which can significantly reduce the level of acute phrase-related reactive protein, the incidene of post-treatment fever and abdominal discomfort and length of hospital stay, which is worthy of promotion.