不同剂量孕激素治疗月经稀发的临床效果

The Clinical Effect of Different Doses of Progesterone in the Treatment of Oligomenorrhea

目的:分析不同剂量孕激素治疗月经稀发的临床效果。方法:选取2018年1-6月笔者所在门诊接诊的月经稀发患者120例为研究对象,随机摸球法分为A组40例,采用6 mg/d孕激素治疗;B组40例,采用10 mg/d孕激素治疗;C组40例,采用15 mg/d孕激素治疗。对比不同剂量孕激素临床治疗效果。结果:三组临床总有效率对比,差异无统计学意义(P>0.05);A组不良反应发生率显著低于B、C组,差异有统计学意义(P<0.05);三组月经周期、月经量、子宫内膜厚度及月经经期对比,差异均无统计学意义(P>0.05)。结论:为月经稀发患者采用不同剂量孕激素治疗时,随剂量提升不良反应发生率持续上升,但治疗总有效率和月经量等指标并未出现较大变化。因此,低剂量孕激素更有应用价值。

Objective:To analyze the clinical effect of different doses of Progesterone in the treatment of oligomenorrhea.Method:A total of 120 patients with oligomenorrhea who were admitted to our outpatient department from January to June 2018 were selected as research objects.According to touch ball method,40 cases were divided into the group A and treated with 6 mg/d Progesterone.And 40 cases were divided into the group B and treated with 10 mg/d Progesterone.And 40 cases were divided into the group C and treated with 15 mg/d Progesterone.The clinical effects of different doses of Progesterone were compared.Result:The total clinical effective rate were compared among the three groups,and the difference was not statistically significant(P>0.05).The incidence of adverse reactions in the group A was significantly lower than that of the group B and the group C,and the difference was statistically significant(P<0.05).Menstrual cycle,menstrual volume,endometrial thickness and menstrual period were compared among the three groups,and the differences were not statistically significant(P>0.05).Conclusion:When patients with Oligomenorrhea are treated with different doses of Progesterone,the adverse reactions continue to increase with the increase of the dose,but there are no significant change in the total effective rate and menstrual volume and other indicators.Therefore,the low dose of Progesterone has more application value.