益肾化湿颗粒辅助西药对慢性肾小球肾炎患者疗效观察

Efficacy of Yishen Huashi Granule Assisted with Western Medicine on Patients with Chronic Glomerulonephritis

目的:探讨益肾化湿颗粒辅助西药治疗慢性肾小球肾炎患者的疗效。方法:选取2018年1月-2019年1月于笔者所在医院就诊的慢性肾小球肾炎患者120例,随机分为对照组与观察组,每组60例,对照组给予缬沙坦治疗,观察组加用益肾化湿颗粒联合缬沙坦治疗,时间均为3个月,比较两组治疗前后的临床疗效、理化指标[24 h蛋白尿定量(24 h Upro)、血尿素氮(BUN)、血清肌酐(Scr)、内生肌酐清除率(Ccr)]和不良反应。结果:治疗后,对照组总有效率为86.67%,观察组为96.67%,组间差异有统计学意义(P<0.05)。两组治疗后的24 h pro、BUN、Scr水平均显著低于治疗前(P<0.05),Ccr水平均显著高于治疗前(P<0.05);治疗后观察组的上述指标均变化幅度大于对照组,组间差异有统计学意义(P<0.05)。对照组不良反应率为10.00%,观察组为6.67%,组间差异无统计学意义(P>0.05)。结论:益肾化湿颗粒联合缬沙坦治疗慢性肾小球肾炎的疗效显著,安全性高,值得推介。

Objective:To explore the efficacy of Yishen Huashi Granule assisted with western medicine in the treatment of patients with chronic glomerulonephritis.Method:120 patients with chronic glomerulonephritis enrolled in our hospital from January 2018 to January 2019 were selected and randomly divided into control group(n=60)and observation group(n=60).Control group was given Valsartan,and observation group was given Yishen Huashi granule combined with Valsartan,and they were treated for 3 months.The clinical efficacy,physicochemical indexes[24 h urine proteinuria(24 h Upro),blood urea nitrogen(BUN),serum creatinine(Ccr),endogenous creatinine clearance rate(Scr)]and adverse reactions were compared between the two groups.Result:After treatment,the total effective rate was 86.67%in control group and 96.67%in observation group(P<0.05).After treatment,the levels of 24 h pro,BUN and Scr in the two groups were significantly lower than those before treatment(P<0.05),while the level of Ccr was significantly higher than that before treatment(P<0.05).The changes of above indexes in observation group after treatment were greater than those in control group(P<0.05).The rate of adverse reactions was 10.00%in control group and 6.67%in observation group(P>0.05).Conclusion:Yishen Huashi Granule combined with Valsartan has significant efficacy on chronic glomerulonephritis,and it has high safety,and it is worthy of recommendation.