白细胞介素1β-31和511基因多态性与原发性高血压的相关性

Interleukin-1β-31 and -511 polymorphisms are associated with essential hypertension

目的探讨白细胞介素1β-31和511基因多态性与原发性高血压的关联性。方法利用PCR-RFLP结合DNA测序验证的方法,检测白细胞介素1β-31和511基因多态性,其中高血压271例,对照组296例,探究两组基因型及等位基因分布情况和不同基因型个体间临床水平。结果白细胞介素1β基因511位点两组间基因型分布差异有统计学意义(P=0.035),高血压组TT基因型明显升高,以CC+CT基因型作参照,TT基因型发生高血压的风险增高,OR=1.557(95%CI=1.059~2.289,P=0.024),而两组间等位基因分布未见统计学差异。白细胞介素1β基因31位点基因型及等位基因分布在高血压组和对照组之间分布差异没有统计学意义(P>0.05)。IL-1β基因511位点,相对于CT+CC基因型,TT基因型舒张压、收缩压明显升高,两者具有统计学差异(P<0.05),而血脂相关指标和体重指数未见统计学差异(P>0.05)。结论 IL-1β基因511多态性与高血压发生有一定的相关性,TT基因型可能增加高血压的易感性。

Objective To investigate the correlations between IL-1β gene 31 and 511 polymorphisms and essential hypertension. Methods A total of 271 essential hypertension and 296 controls were enrolled for polymorphisms detection at 31 and 511 of IL-1β by PCR-RFLP and DNA sequencing. The distribution of genotypes and alleles in the two groups and the clinical levels of individuals with different genotypes were analyzed. Results The distribution of IL-1β-511 genotype has statistically significant difference between control and essential hypertension groups(P=0.035). TT genotype of IL-1β-511 was obviously higher in essential hypertension group. Compared with CT+CC genotype, TT genotype showed an increased risk to develop essential hypertension(OR=1.577, 95%CI=1.059-2.289, P=0.024). There was no statistically significant difference between the two groups regarding genotypes or alleles of IL-1β-31. Compared with CT+CC genotype, diastolic blood pressure and systolic blood pressure in TT genotype were significantly increased. But there were no statistically significant difference regarding blood lipid or body mass index at position 511 of IL-1β. Conclusion IL-1β gene 511 polymorphism is associated with essential hypertension, and the TT genotype may increase the susceptibility to essential hypertension.