血清Hcy、CEA、CA199对结直肠癌诊断价值及其分期的相关性研究

Correlation between serum Hcy, CEA and CA199 in diagnosis and staging of colorectal cancer

目的评估血清Hcy、CEA、CA199对结直肠癌的诊断价值及与其分期的相关性。方法选取2017年1月~2018年7月于兰州大学第一医院住院的CRC患者80例及健康查体者80例,详细记录了就诊时血清Hcy、CEA、及CA199的值。对两组观察对象Hcy、CEA、及CA199的值进行对比,并分析不同临床病理参数下各标记物的阳性率。结果结直肠癌组的血清Hcy、CEA、CA199水平明显高于健康对照组(P<0.001)。Ⅲ、Ⅳ期患者血清标记物水平显著高于Ⅰ、Ⅱ期;将三种标记物联合检测时能提高诊断效能。结论 Hcy、CEA、CA199可作为结直肠癌的血清标记物用于临床癌前筛查和早期诊断。

Objective To evaluate the diagnostic value of serum Hcy, CEA and CA199 for colorectal cancer and its correlation with staging. Methods 80 CRC patients and 80 healthy subjects were enrolled in the First Hospital of Lanzhou University from January 2017 to July 2018. The values of serum Hcy, CEA and CA199 were recorded in detail. The values of Hcy, CEA, and CA199 were compared between the two groups, and the positive rate of each marker under different clinicopathological parameters was analyzed. Results The values of Hcy, CEA and CA199 in the colorectal cancer group were significantly higher than those in the healthy control group(P<0.001). The levels of serum markers in patients with stage Ⅲ and Ⅳ were significantly higher than those in stages Ⅰ and Ⅱ. Combined detection of the three markers improved the diagnostic efficacy. Conclusion Hcy, CEA and CA199 can be used as serum markers for colorectal cancer for preclinical screening and early diagnosis.