KCNE2基因与新疆维吾尔族人群慢性心力衰竭的相关性

Correlation between KCNE2 gene and chronic heart failure in Xinjiang Uygur population

目的探讨KCNE2基因与新疆维吾尔族人群慢性心力衰竭(chronic heart failure, CHF)的关系。方法新疆维吾尔族CHF患者172例为CHF组,无CHF且左室射血分数>50%患者196例为对照组,比较2组临床资料,并采用PCR-DNA测序法分析KCNE2基因多态性,采用多因素logistic回归分析新疆维吾尔族人群发生CHF的危险因素。结果 CHF组左心室舒张末期内径、QRS时限、血清总胆固醇水平及冠心病、糖尿病比率明显高于对照组(P<0.05),左室射血分数低于对照组(P<0.05);CHF组AA基因型频率(55.23%)和A等位基因分布频率(72.97%)明显高于对照组(38.78%、61.48%)(P<0.05);糖尿病史(OR=3.392,95%CI:1.324~8.685,P=0.011)、冠心病史(OR=4.179,95%CI:1.970~8.861,P<0.001)、左心室舒张末期内径增大(OR=1.411,95%CI:1.309~1.521,P<0.001)、QRS时限延长(OR=1.022,95%CI:1.003~1.041,P=0.021)、KCNE2基因603A-T(34371081)多态位点AA基因型(OR=2.127,95%CI:1.062~4.260,P=0.033)为新疆维吾尔族人群发生心力衰竭的独立危险因素(P<0.05)。结论 KCNE2基因与新疆维吾尔族人群CHF的发生密切相关,携带AA基因型者患CHF的风险增加。

Objective To investigate the correlation between KCNE2 gene and chronic heart failure(CHF) in Xinjiang Uygur population. Methods PCR-DNA sequencing was used to study the single nucleotide polymorphism of KCNE2 gene in 172 Xinjiang Uygur patients with CHF(CHF group) and 196 patients without CHF and left ventricular ejection fraction(LVEF)>50%(control group). The clinical data were compared between two groups. Multivariate logistic regression was used to analyze the risk factors of CHF in Xinjiang Uygur patients. Results The left ventricular end-diastolic dimension, QRS duration, serum total cholesterol level, and the percentages of coronary heart disease and diabetes mellitus were higher in CHF group than those in control group(P<0.05), and LVEF was significantly lower in CHF group than that in control group(P<0.05). AA genotype frequency and A allele frequency were significantly higher in CHF group(55.23%, 72.97%) than those in control group(38.78%, 61.48%)(P<0.05). The history of diabetes mellitus(OR=3.392, 95%CI: 1.324-8.685, P=0.011) and coronary heart disease(OR=4.179, 95%CI: 1.970-8.861, P<0.001), increased left ventricular end-diastolic dimension(OR=1.411, 95%CI: 1.309-1.521, P<0.001), prolonged QRS duration(OR=1.022, 95%CI: 1.003-1.041, P=0.021), and KCNE2 gene 603 A-T(34371081) polymorphic site AA genotype(OR=2.127, 95%CI: 1.062-4.260, P=0.033) were the independent risk factors for CHF in Xinjiang Uygur population(P<0.05). Conclusion KCNE2 gene is closely correlated with the occurrence of CHF in Xinjiang Uygur population, and the patients with AA genotype have high risk of CHF.