耳穴贴压干预成年患者焦虑的Meta分析

Meta-analysis of auricular-plaster therapy intervening with anxiety in adults

目的评价耳穴贴压干预成年患者焦虑情绪的应用效果。方法电子检索Cochrane Library、PubMed、Embase、中国生物医学文献数据库、CNKI、万方数据库,按照纳入和排除标准,筛选耳穴贴压治疗成年患者焦虑的随机对照试验,由2人独立进行文献质量评鉴和数据提取,对于焦虑指标采用多时间点Meta分析,而对于睡眠和生活质量指标则采用终末时间点Meta分析。采用RevMan5.3进行统计分析。结果最终纳入15篇文献,包括890例研究对象。Meta分析结果显示,2个月内耳穴贴压对焦虑可产生持续的、高等程度的改善效果(P<0.01),但干预后2个月,差异无统计学意义(P>0.05);耳穴贴压能够改善睡眠质量,且干预效果为高度效应(P<0.001);尚无证据证明耳穴贴压能够改善焦虑患者生活质量(P>0.05)。结论耳穴贴压能够改善患者的焦虑和睡眠质量,但鉴于纳入研究质量和数量的限制,本研究结论尚有赖于大样本、多中心、高质量的随机对照试验,尤其是长期干预疗效研究加以验证。

Objective To review the intervention effects of auricular-plaster therapy on adults with anxiety systematically. Methods Data about random controlled trails of auricular-plaster therapy in treating anxiety were collected from Cochrane, PubMed, Embase, CBMdisc, CNKI and Wanfang databases. The quality of literatures were assessed and the data were collected by two persons independently. Multiple-time-point Meta-analysis was used for anxiety, while endpoint Meta-analysis was used for quality of sleep and life. RevMan 5.3 was used for statistical analysis. Results Totally 15 literatures were included in this study, involving 890 subjects. Meta-analysis showed that auricular-plaster therapy could ameliorate anxiety continuously with high degrees within 2 months (P<0.01), but there were no notable effects yet beyond 2 months (P>0.05). Auricular-plaster therapy could improve the quality of sleep effectively (P<0.001). There was no evidence that auricular-plaster therapy could improve the quality of life (P>0.05). Conclusions Auricular-plaster therapy can ameliorate patients' anxiety and improve their quality of sleep, but considering the limited quality and quantity of studies included, the findings of our study will need to be tested by multicenter and high-quality random controlled trails with large samples, especially its long-term intervention effects.