弯曲菌对氟喹诺酮类抗生素耐药性及耐药机制研究进展

Resistance of Campylobacter and its resistance mechanisms to fluoroquinolones

弯曲菌(Campylobacter)是一类全球普遍关注的人兽共患病病原菌,也是引发人类急性胃肠炎的主要食源性致病菌之一。氟喹诺酮类药物是临床治疗弯曲菌感染性疾病的经验用药,但在动物疫病和人类医疗中过度使用抗生素导致了耐药弯曲菌的增加,近年来世界各地陆续出现弯曲菌对氟喹诺酮类抗生素耐药的研究报道。本文就氟喹诺酮类抗生素的杀菌机制、弯曲菌对氟喹诺酮类抗生素的耐药现状和耐药机制进行综述,为氟喹诺酮类抗生素对弯曲菌的合理应用提供一定的参考。

Campylobacter is a kind of zoonotic pathogen which is widely concerned in the world.It is also one of the main foodborne pathogens causing acute gastroenteritis in humans.Fluoroquinolone is an empirical drug for the clinical treatment of Campylobacter infections.However,excessive use of antibiotics in animal diseases and human medical treatment has led to an increase in resistance to Campylobacter.In recent years,studies on the resistance of Campylobacter to fluoroquinolones have been reported around the world.This paper reviewed the bactericidal mechanism of fluoroquinolones,the present situation of drug resistance of Campylobacter to fluoroquinolones and the mechanism of drug resistance,so as to provide some references for the rational application of fluoroquinolones for Campylobacter.