哺乳动物睾丸精子发生中Wnt信号通路的研究进展

Roles of Wnt signaling pathway in mammalian testicular spermatogenesis

Wnt信号通路在哺乳动物睾丸精子发生过程中发挥着重要作用,其异常与男性不育密切相关.本文综述了Wnt信号通路在原始生殖细胞增殖、精原细胞自我更新、精子发生和睾丸体细胞中的调控作用及其分子机制,探讨了Wnt信号通路与男性不育的关系及用于研究男性生育功能Wnt信号通路动物模型,并总结了哺乳动物睾丸精子发生中Wnt信号通路的研究进展.

Wnt signaling pathway presents critical roles in mammalian testicular spermatogenesis while the abnormality of Wnt signaling is closely related to male infertility. This article summarizes the regulation function and molecular mechanism of Wnt signaling pathway in primary germ cell proliferation, spermatogonial cell self-renew, spermatogenesis and testicular somatic cell. Moreover, we introduce the relationship between Wnt signaling pathway and male infertility and a number of animal models related to Wnt signaling pathway. Finally, we describe the study progress of Wnt signaling pathway in mammalian testicular spermatogenesis.