子宫内膜癌组织中丛生蛋白的表达及其与雌激素受体、孕激素受体的关系

Expression of cluster proteins in endometrial carcinoma and its relationship with ER and PR

目的探讨子宫内膜癌组织中丛生蛋白的表达及其与雌激素受体(ER)、孕激素受体( PR)的相关性.方法选择湖州市妇幼保健院2013年1月至2017年12月子宫内膜癌组织标本120例和正常子宫内膜组织标本120例进行研究,采用免疫组化法测定组织中丛生蛋白、ER、PR表达.结果子宫内膜癌组织中丛生蛋白阳性率(89.2%)高于正常子宫内膜组织(13.3%)(χ^2=145.067,P<0.05),ER、PR阳性表达率(60.0%、56.7%)均低于正常子宫内膜组织(100.0%、100.0%)(χ^2=93.490、96.698,均P<0.05);子宫内膜癌组织中丛生蛋白与ER、PR均呈负相关(r=-0.472、-0.513,均P<0.05);子宫内膜癌组织中丛生蛋白和ER阳性表达与子宫内膜癌的国际妇产科联合会(FIGO)分期、肌层浸润深度和淋巴结转移有关(83.1%比93.0%、82.6%比98.0%、97.6%比84.6%;81.7%比29.2%、91.3%比17.6%、19.5%比82.1%)(χ^2=6.628、7.228、4.779,33.062、66.292、43.984,均P<0.05),与年龄、分化程度、肿瘤直径无关(P>0.05);子宫内膜癌组织中PR阳性表达与子宫内膜癌的FIGO分期、肌层浸润深度有关(78.9%比24.5%、84.1%比20.0%)(χ^2=34.919、48.577,均P<0.05),与年龄、分化程度、肿瘤直径和淋巴结转移无关(均P>0.05).结论子宫内膜癌的发生发展与丛生蛋白的过度表达有关,丛生蛋白的表达情况可能受雌激素和孕激素调控.

Objective To investigate the expression of cluster proteins in endometrial cancer tissues and its correlation with estrogen receptor (ER) and progesterone receptor (PR). Methods We selected 120 cases of endometrial cancer tissue specimens and 120 cases of normal endometrial tissue specimens from January 2013 to December 2017 in the Maternal and Child Health Hospital of Huzhou.The expression of cluster proteins, ER and PR in tissues were determined by immunohistochemistry. Results The positive rate of cluster proteins in the endometrial carcinoma tissues(89.2%) was higher than that in the normal endometrial tissues(13.3%)(χ2=145.067, P<0.05). The positive expression rates of ER and PR in the endometrial carcinoma tissues(60.0%, 56.7%) were lower than those in the normal endometrial tissues(100.0%, 100.0%)(χ2=93.490, 96.698, all P<0.05). The cluster proteins was negatively correlated with ER and PR in the endometrial carcinoma tissues (r=-0.472,-0.513, all P<0.05). The expression of cluster protein and ER in the endometrial carcinoma were associated with FIGO stage, depth of myometrial invasion and lymph node metastasis of endometrial carcinoma(83.1% vs.93.0%, 82.6% vs.98.0%, 97.6% vs.84.6%;81.7% vs.29.2%, 91.3% vs.17.6%, 19.5% vs.82.1%)(χ2=6.628, 7.228, 4.779;33.062, 66.292, 43.984, all P<0.05), and were not associated with age, degree of differentiation and tumor diameter (all P>0.05). The positive expression of PR in the endometrial carcinoma was correlated with the FIGO stage and depth of myometrial invasion of the endometrial carcinoma(78.9% vs.24.5%, 84.1% vs.20.0%,χ2=34.919, 48.577, all P<0.05), and were not associated with age, degree of differentiation, tumor diameter and lymph node metastasis (all P>0.05). Conclusion The development of endometrial cancer is related to the overexpression of cluster proteins, and the expression of cluster proteins may be regulated by estrogen and progesterone.