丹红注射液联合玻璃酸钠关节腔内注射对胫骨骨折患者血清骨性标志物水平的影响

Effects of Danhong Injection Combined with Sodium Hyaluronate Intra-articular Injection on Serum Levels of Bone Markers of Patients with Tibial Fracture

目的:研究丹红注射液联合玻璃酸钠关节腔内注射对胫骨骨折术后血清骨性标志物水平的影响。方法:研究对象选取我院2015年5月到2016年8月间收治的胫骨骨折患者110例,所有患者均行切开复位内固定手术治疗。采用随机数字法将其分为对照组和观察组,每组各55例。对照组患者玻璃酸钠关节腔内注射治疗,观察组患者配合丹红注射液。比较两组患者的治疗疗效、治疗前后的视觉模拟评分法(VAS评分)、血清骨钙素(bone Glaprotein,BGP)、I型前胶原羧基端肽(carboxyterminal propeptide of type I procollagen,PICP)水平的变化。结果:治疗后1、3、7天患处疼痛VAS评分均明显低于对照组(P<0.05),治疗后1、2、4周观察组患者关节活动度评分均明显高于对照组(P<0.05),治疗后观察组患者血清BGP、PICP水平均明显高于对照组(P<0.05)。结论:丹红注射液联合玻璃酸钠关节腔内注射能够促进胫骨骨折术后骨折愈合,提高临床疗效。可能与其有效提高患者血清BGP、PICP水平有关。

Objective: To study the effects of Danhong injection combined with sodium hyaluronate intra-articular injection on the serum levels of bone markers of patients with tibial fracture. Methods: 110 cases of patients with tibial fracture in our hospital from May 2015 to August 2016 were randomly divided into the control group and the observation group, 55 cases in each group. The patients in the control group were treated with intra-articular injection of sodium hyaluronate treatment, the observation group were treated with Danhong injection on the basis of control group. The total efficiency, visual analogue score(VAS) and serum bone Glaprotein(BGP)and carboxyterminal propeptide of type I procollagen(PICP)before and after treatment were compared between two groups. Results: On the 1 st,3 rd, 7 thday after treatment, the pain VAS score were significantly lower than those of the control group(P<0.05);at 1, 2, 4 weeks after treatment, the joint mobility scores of observation group were significantly higher than those of the control group(P<0.05);the serum BGP and PICP levels of the observation group were significantly higher than those of the control group(P<0.05). Conclusion: Danhong injection can promote the fracture healing, improve the clinical efficacy,which may be related to the improvement of serum BGP and PICP levels.