应用CBCT测量慢性牙周炎患者口服维生素D3牙槽骨密度改变的临床研究

Clinical study of alveolar bone mineral density changes in patients with chronic periodontitis treated with oral vitamin D3 by CBCT

目的应用锥形束计算机断层扫描(cone beam computed tomography,CBCT)观察慢性牙周炎患者口服维生素D3前后牙槽骨密度的变化。方法随机选取我科60例50~59岁慢性牙周炎患者口服维生素D3 12个月,应用CBCT分别测量左上中切牙、尖牙、第一磨牙近远中、颊舌侧4个位点的近远中侧牙槽间隔顶及颊舌侧牙槽嵴顶至根尖水平牙槽骨密度,评价口服维生素D3后牙槽骨密度的差异有无统计学变化。结果研究对象经过6个月后第1次观测牙槽骨密度差异无统计学变化,经过12个月后第2次观测牙槽骨密度差异较前有统计学变化(P<0.05)。结论研究表明短期口服维生素D3对慢性牙周炎患者牙槽骨密度变化有统计学意义。

Objective To observe the changes of alveolar bone density in patients with chronic periodontitis before and after oral administration of vitamin D3 by cone beam computed tomography(CBCT). Methods Sixty 50-to 59-year-old patients with chronic periodontitis were selected and took vitamin D3 orally for 12 months. CBCT was used to measure the alveolar bone density at the proximal and distal alveolar septum and the alveolar ridge to the level of alveolar bone in the mesial, distal, buccal and lingual sides of left upper central incisors, canines, and first molars. Whether there was a statistical difference in alveolar bone density was evaluated after the oral administration of vitamin D3. Results There was no statistical significance in the difference of bone mineral density during the first observation after 6 months, but the difference of alveolar bone density during the second observation after 12 months was statistically significant(P<0.05). Conclusion This study shows that short-term oral administration of vitamin D3 has significant difference in alveolar bone density in patients with chronic periodontitis.