胰岛素泵可降低糖尿病患儿血清的HMGB1水平

Insulin Pump Therapy can Reduce Serum HMGB1 Level in Children with Diabetes Mellitus

为了探讨胰岛素泵治疗对儿童糖尿病患者血清人高迁移率族蛋白B1 (human high mobility groupprotein B1, HMGB1)水平的影响,本研究选择1 型糖尿病(type 1 diabetes mellitus, T1DM)患儿64 例,随机分为胰岛素泵治疗组(观察组)和多次注射胰岛素治疗组(对照组),比较两组糖尿病患儿的空腹血糖(fastingblood glucose, FBG)以及餐后2 h 血糖(2 h FBG)、血糖达标时间以及胰岛素用量以及治疗前后的糖化血红蛋白(HbAlc)、C 肽和HMGB1水平。结果显示,与对照组比较,观察组的FBG 以及2h FBG、血糖达标时间以及胰岛素用量均明显低于对照组,差异均存在统计学意义(p<0.05)。与对照组糖尿病患儿治疗后的结果比较,观察组的HbA1c 水平明显降低,C 肽含量明显升高,差异均存在统计学意义(p<0.05)。本研究还发现与对照组糖尿病患儿治疗后的结果比较,观察组治疗后的HMGB1水平明显降低,差异均存在统计学意义(p<0.05)。本研究研究结论初步表明,胰岛素泵治疗对儿童糖尿病的改善作用可能与其降低HMGB1水平有关。

To investigate the effect of insulin pump therapy on serum Human High mobility group protein B1 (HMGB1) level in children with diabetes mellitus. 64 type 1 diabetes mellitus (T1DM) patients from June 2017 to October 2018 in our hospital were selected and randomly divided into insulin pump treatment group (observation group) and repeated injections of insulin treatment group (control group). Fasting blood glucose (FBG) and 2 h postprandial blood glucose (FBG), blood glucose therapeutic time, dosage of insulin, glycosylated hemoglobin (HbAlc), C peptide as well as HMGB1 levels between two groups of children with diabetes were compared. Compared with the control group, FBG, 2 h FBG, blood glucose therapeutic time, dosage of insulin in the observation group were significantly lower than those in the control group (p<0.05). Compared with the results of the control group after treatment, the HbA1c in the observation group after treatment was significantly reduced and c-peptide was significantly increased (all p<0.05). In this study, it was also found that the HMGB1 level in the observation group after treatment was lower than that in the control group after treatment (p<0.05). Our research conclusions preliminarily indicate that the improvement effect of insulin pump on diabetes in children may be related to the decrease in HMGB1 level.