急性中央颈髓损伤综合征合并慢性损伤动物模型的建立

Establishment of Animal Model of Acute Central Cervical Spinal Cord Injury Syndrome Combined with Chronic Injury

为了制定急性中央颈髓损伤综合征的大动物模型,本研究将20只成年雄性山羊随机分为A组(急性后路球囊压迫)、B组(慢性螺钉前路压迫)、C组(慢性前路螺钉压迫结合急性后路球囊压迫)和D组(假手术组),通过评估运动功能、CT、MRI、皮层体感诱发电位和病理变化,以期为临床治疗提供参考。研究表明C组山羊运动功能明显低于其他各组。CSEP在脊髓压迫前呈现稳定的模式。脊髓压迫导致峰值潜伏期逐渐减少,而峰值振幅显著增加。C组颈椎椎管占位比明显低于其他各组。MRI显示C组的T1加权像为局灶性低信号,T2加权像为局灶性高信号。病理分析显示C组的灰质病变较白质病变严重。初步研究表明,该模型很好地模拟了ACCSCIS的发病机制和临床特点。

To develop a large animal model of ACCSCIS, 20 adult male goats were randomly divided into 4 groups: group A (Acute posterior balloon compression), group B (Chronic anterior screw compression), group C (Compression of acute posterior balloon compression and chronic anterior screw compression) and D Group (Sham operation group). Motor function, CT, MRI, cortical somatosensory evoked potential and pathological changes were evaluated to provide reference for clinical treatment. The results showed that the motor function of group C was significantly lower than that of other groups. CSEP showed a stable pattern before spinal cord compression. Spinal cord compression results in a gradual decrease in peak latency and a significant increase in peak amplitude. The cervical canal occupying ratio in group C was significantly lower than that in other groups. MRI showed that T1-weighted images in group C presented focal low signal and T2 weighted images presented focal high signal. Pathological analysis showed that gray matter lesions were more serious than white matter lesions in group C. Preliminary study shows that the model can well simulate the pathogenesis and clinical characteristics of ACCSCIS.