糖化血红蛋白指数与2型糖尿病患者颈动脉内中膜厚度的相关性研究

Correlation between hemoglobin glycation index and carotid intima-media thickness in patients with type 2 diabetes mellitus

目的探讨2型糖尿病患者糖化血红蛋白指数(HGI)与颈动脉内中膜厚度(CIMT)的相关性。方法选择2015年1月至2018年6月在扬州大学临床医学院住院的2型糖尿病患者462例并收集其临床资料,依据HGI值,采用三分位数法将患者分为低HGI组、中HGI组和高HGI组,比较三组间各指标差异并分析HGI与CIMT的相关性。结果三组性别、年龄、糖尿病病程、体质指数、收缩压、舒张压、空腹血糖、白细胞计数、高密度脂蛋白胆固醇、尿酸比较,差异未见统计学意义(P>0.05);而糖化血红蛋白、餐后2h血糖、空腹C肽、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、CIMT及CIMT增厚比例组间比较,差异有统计学意义(P<0.05)。Logistic回归分析发现,HGI升高是颈动脉内膜增厚的独立危险因素(OR=1.158,95%CI:1.022~1.312)。结论HGI对于预测T2DM患者心血管疾病的发生有重要参考价值。

Objective To study the correlation between hemoglobin glycation index (HGI) and carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM). Methods A total of 462 patients with T2DM hospitalized in the Clinical Medical College of Yangzhou University from January 2015 to June 2018 were selected and their clinical data were collected. According to HGI value, patients were divided into low HGI group, medium HGI group and high HGI group by tri-quartile method. The differences of each index among the three groups were compared and the correlations between HGI and CIMT were analyzed. Results There was no significant difference in these indexes among the three groups, including sex, age, course of diabetes, body mass index, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, white blood cell count, high density lipoprotein cholesterol and serum uric acid (P>0.05). However, the levels of glycation hemoglobin, postprandial 2-hour plasma glucose, fasting C-peptide, total cholesterol, triglyceride, low density lipoprotein cholesterol, CIMT and number of patients with incrassated CIMT were significantly different among the three groups (P<0.05). Logistic regression analysis showed that elevated HGI was an independent risk factor for increased CIMT (OR=1.158, 95% CI: 1.022- 1.312). Conclusions HGI has important reference value in predicting the occurrence of cardiovascular disease in patients with T2DM.