钙结合蛋白与血清催乳素昼夜变化在首发精神分裂症病人中的诊断价值及其相关性

The diagnostic value and correlation between calcium binding protein and serum prolactin diurnal changes in patients with first-episode schizophrenia

目的探讨钙结合蛋白(S100-β)、血清催乳素(PRL)两种血清蛋白因子昼夜变化在首发精神分裂症病人中的诊断价值及其相关性研究。方法分别选取2017年1月至2018年1月衡水市精神病医院45例以阳性症状为主和45例阴性症状为主的首发精神分裂症病人以及45名健康人群作为研究对象,采用酶联吸附技术(ELISA)分别测定三组在两个时间段(12:00和0:00)S100-β、PRL的浓度,通过阳性与阴性症状量表(PANSS)量表对首发精神分裂症病人的症状进行定量评估。结果在两个时间段(12:00和0:00)三组血清S100-β浓度健康对照组低于阳性组和阴性组(P<0.05),并且在午夜时间段(0:00)阳性组S100-β浓度(132.46±40.19)ng/L高于阴性组(123.36±43.37)ng/L(P<0.05);阳性组在午夜时间段(0:00)的S100-β浓度高于中午时间段(12:00)(123.98±43.14)ng/L(P<0.05)。在两个时间段(12:00和0:00)三组血清PRL浓度健康对照组低于阳性组和阴性组(P<0.05)。阳性组病人的S100-β水平与PANSS阳性症状评分存在显著相关(r=0.56,P=0.009)。结论首发精神分裂症病人S100-β、PRL血清蛋白因子分泌异常,且以阳性症状为主的病人更明显。此外,两种血清蛋白昼夜的动态变化阐释了首发精神分裂症病人的临床状态。

Objective To investigate the diagnostic value and correlation of diurnal changes of S100-binding protein β(S100-β) and prolactin in patients with first-episode schizophrenia.Methods From January 2017 to January 2018,45 patients with first epi- sode schizophrenia and 45 patients with negative symptoms in Hengshui Psychiatric Hospital and 45 healthy people were selected as research objects..The serum levels of S100-β and prolactin were measured by enzyme-linking immunosorbent assay(ELISA). Positive symptom,negative symptom scores were measured by Positive and Negative Syndrome Scale(PANSS)in patients and controls.Results S100-β serum level in the control group was significantly lower than that of positive and negative groups(P<0.05). S100-β serum level in day was lower than that at night [(132.46±40.19)ng/L vs.(123.98±43.14)ng/L].PRL serum level in the control group was significantly lower than those of positive and negative groups(P<0.05).In addition,there was significant correla- tion between serum S100 β protein levels and the PANSS positive subscale(r=0.56,P=0.009).Conclusion The S100 and PRL of patients with first-episode schizophrenia were significantly different from that in the control group,and the diurnal and nocturnal changes in serum levels of S100 β were more significant.The significant positive correlation between serum S100-β concentration and PANSS positive score,as well as diurnal variation may explain the clinical state of the patient’s biological response.