微生态制剂预防先天性巨结肠术后小肠结肠炎疗效观察

Observation on the ffect of microecological preparations on preventing perioperative enterocolitis of congenital megacolon

目的观察微生态制剂(双歧杆菌乳杆菌三联活菌)预防先天性巨结肠术后小肠结肠炎的临床效果。方法选取2014年8月至2017年12月郑州儿童医院先天性巨结肠术后病儿86例,采用随机数字表法分为对照组和观察组各43例,对照组采用常规处理,观察组采用微生态制剂防治,比较治疗后两组小肠结肠炎发生情况和肠道菌群变化情况。结果观察组治疗后小肠结肠炎发生率为4.7%(2/43),Ⅰ期1例,Ⅱ期1例。对照组治疗后小肠结肠炎发生率为18.6%(8/43),Ⅰ期4例,Ⅱ期3例,Ⅲ期1例,差异有统计学意义(P<0.05);治疗后,观察组杆菌总数为(236.33±26.94)fu/g,球菌总数为(88.73±9.11)fu/g,球杆菌比值为(1.58±0.26)%,对照组为(104.59±10.53)fu/g,(51.60±5.45)fu/g,(2.98±0.29)%,观察组杆菌总数、球菌总数多于对照组,球杆菌比值少于对照组,差异有统计学意义(P<0.05)。结论微生态制剂能预防先天性巨结肠手术后小肠结肠炎的发生,调控肠道菌群,改善预后,值得推广。

Objective To observe the clinical effect of microecological preparations(bifidobacteria lactobacillus trifecta)in preventing perioperative enterocolitis of congenital megacolon.Methods From August 2014 to February 2017,86 cases of children with congenital megacolon after operation in Zhengzhou Children’s Hospital were divided into the control group,treated with conventional treatment and the treatment group,treated with microecological preparations,with 43 cases in each.The incidence of enterocolitis and intestinal flora of the two groups were compared.Results The incidence of enterocolitis in the experimental group was 4.7%(2/43),with one case in phase Ⅰ and one case in phase Ⅱ.The incidence of enterocolitis in the control group was18.6%(8/43),with 4 cases in phase Ⅰ,3 in phase Ⅱ,and 1 in phase Ⅲ,with statistical differences(P<0.05).After treatment,the total number of bacillus[(236.33 ± 26.94)fu/g vs.(104.59 ± 10.53)fu/g]and coccus[(88.73 ± 9.11)fu/g vs.(51.60 ± 5.45)fu/g]in the experimental group was higher than that in the control group,and the ratio of bacillus and coccus was lower than that in the control group[(1.58±0.26)% vs.(2.98±0.29)%],with statistical differences(P<0.05).Conclusion The microecological preparations can prevent the occurrence of enterocolitis after operation of congenital megacolon,regulate intestinal flora and improve the prognosis,which is worth popularizing.