白假丝酵母与口腔常见细菌相互作用的进展研究

Research progress on cross-kingdom interactions between Candida albicans and common oral bacteria

白假丝酵母是人体正常的共生菌群,在健康成人口腔中,白假丝酵母的检出率为30%~50%。同时白假丝酵母也是一种机会致病菌,常可造成人体皮肤、黏膜、血液系统等部位的感染。在其感染过程中,常伴有与不同细菌的混合感染。在口腔中,白假丝酵母可与多种细菌一起参与龋病、义齿性口炎、黏膜感染等疾病的发生与发展。本文对白假丝酵母与口腔常见细菌的相互作用以及其可能机制进行综述,以为临床对口腔常见疾病的诊断、预防、治疗等提供新思路。

Candida albicans is one of the most prevalent commensal species of human microbiota, which can be detected in the oral cavity of 30%-50% healthy adults. However, it is also an opportunistic pathogen that can cause severe skin, mucosal or bloodstream infections. The impact of C. albicans typically depends on its interaction with bacteria. For example, together with other bacteria, C. albicans can participate in the development of caries, denture stomatitis and mucosal infections. Therefore, in this review, the interactions between C. albicans and common oral bacteria and the possible mechanisms are summarised, thereby providing novel ideas on the clinical prevention and treatment of common oral diseases.