和胃降逆汤配合药穴指压治疗湿热型胆汁反流性胃炎的临床研究

Clinical Study on Hewei Jiangni Decoction Combined with Medicine Acupoint Finger-pressing in Treating Damp-heat Type Bile Reflux Gastritis

目的观察常规西药基础上和胃降逆汤配合药穴指压治疗湿热型胆汁反流性胃炎的临床疗效与安全性。方法选取2015年12月至2017年12月在本院接受治疗的湿热型胆汁反流性胃炎患者116例,按照随机数字表法分成两组,对照组(58例)行西医常规治疗,观察组(58例)在对照组基础上加服和胃降逆汤并配合药穴指压。对比分析两组患者血清脂质过氧化物(Lipidperoxide,LPO)、P物质(SubstanceP,SP)、降钙素基因相关肽(Calcitoningene-relatedpeptide,CGRP)、5-羟色胺(Hydroxytryptamine,5-HT)、胃促生长素(Ghrelin)、血管活性肽(Vasoactiveintestinalpeptide,VIP)含量,胃黏膜组织白细胞介素-23(Interleukin-23,IL-23)、IL-17mRNA(Interleukin-23mRNA,IL-17mRNA)相对表达量及不良发应状况。结果治疗后,两组患者的血清LPO、SP、5-HT、VIP、CGRP含量、胃黏膜IL-23、IL-17mRNA相对表达量、胃内胃酸及胆酸吸出量相对于治疗前均有所降低,血清Ghrelin含量较治疗前均有所升高,差异有统计学意义(P<0.05或P<0.01);治疗后观察组的上述指标的改变均优于对照组,且差异具有统计学意义(P<0.05)。结论在常规西药的基础上采用和胃降逆汤配合药穴指压治疗胆汁反流性胃炎患者疗效显著,可缓解患者体内炎症反应程度,降低胆酸、胃酸分泌量,使患者更快康复。

Objective To observe the clinical efficacy and safety of conventional Western medicine with Hewei Jiangni Decoction and medicine point finger-pressing in treating damp-heat type bile reflux gastritis. Methods A total of 116 patients with damp-heat type bile reflux gastritis who were treated in our hospital from December 2015 to December 2017 were selected and divided into 2 groups according to random number table method. Control group (58 cases) was given conventional Western medicine treatment. On the treatment basis of the control group, Hewei Jiangni Decoction was added, combined with medicine acupoint finger-pressing, in observation group (58 cases). Comparative analysis was performed on serum content of lipid peroxide (LPO), substance P (SP), calcitonin gene-related peptide (CGRP), Hydroxytryptamine (5-HT), Ghrelin, and vasoactive intestinal peptide (VIP), relative expression of gastric mucosal tissue interleukin-23 (IL-23), and IL-17 mRNA, as well as adverse reactions in the 2 groups. Results After the treatment, the serum content of LPO, SP, 5-HT, VIP and CGRP, relative expression of IL-23 and IL-17 mRNA in gastric mucosa, and extraction volume of gastric acid and cholic acid in patients of the observation group and the control group were decreased compared with those before the treatment, and the serum content of Ghrelin was increased compared with that before the treatment, with statistically significant difference (P<0.05 or P<0.01). After the treatment, changes of the above indexes in the observation group were better than those in the control group, and the difference was statistically significant (P<0.05). Conclusion Hewei Jiangni Decoction combined with medicine acupoint finger-pressing on the basis of conventional Western medicine in patients with bile reflux gastritis has significant efficacy, which can alleviate the degree of inflammatory reaction in patients, decrease the volume of cholic acid and gastric acid secretion, and make patients recover faster.