CA72-4、CA19-9、CEA联合检测在胃癌诊断中的临床意义

Clinical significance of combined detection of CA72-4,CA19-9 and CEA in diagnosis of gastric cancer

目的探讨肿瘤标志物糖类抗原72-4(CA72-4)、糖类抗原19-9(CA19-9)、癌胚抗原(CEA)联合检测在胃癌诊断中的临床意义。方法选取2017年01月至2018年07月在蚌埠市第三人民医院就诊的37例胃癌患者为观察组,44例胃良性疾病患者为对照组,予以检测CA72-4、CA19-9、CEA数值,并回顾性分析患者的临床资料。结果观察组患者CA72-4、CA19-9、CEA检测值均高于对照组患者,差异均具有统计学意义(P<0.05)。3种肿瘤标志物单项检测差异无统计学意义(P>0.05)。而联合检测的灵敏度为91.89%,特异度为95.45%,且灵敏度高于单项检测,差异具有统计学意义(P<0.05)。结论 CA72-4、CA19-9、CEA与胃癌均有一定的相关性,且其联合检测灵敏度及特异度更高,更有助于胃癌的诊断。

Objective To explore Clinical significance of combined detection of CA72-4,CA19-9 and CEA in diagnosis of gastric cancer.Methods 37 cases of gastric cancer in Beng Bu Third People’Hospital,from January 2016 to July 2018,were selected as the observation group,and 44 cases of benign gastric diseases were selected as the control group,then measured the CA72-4,CA19-9 and CEA values and retrospective analyzed their clinical data.Results The values of CA72-4,CA19-9 and CEA in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in single tumor detection between the 3 tumor markers(P>0.05).The sensitivity and specificity of combined detection were 91.89% and 95.45% respectively,and the sensitivity was higher than that of single detection,the difference was statistically significant(P<0.05).Conclusion There is a certain correlation between CA72-4,CA19-9,CEA and gastric cancer,and their sensitivity and specificity are higher when combined detection,which is more conducive to the diagnosis of gastric cancer.