微小RNA在新生儿缺血缺氧性脑病中的表达

MicroRNA expression of hypoxic-ischemic encephalopahty in newborn

微小RNA(miRNA)是一类高度保守的内源性小分子RNA。miRNA主要通过选择性结合mRNA调控基因表达。目前研究结果表明,中枢神经系统存在大量miRNA,并参与神经细胞的正常生长、发育,以及组织损伤修复、肿瘤发生、神经退行性变等多种病理、生理过程。笔者拟就新生儿缺血缺氧性脑病(HIE)miRNA谱系的最新研究进展进行阐述,探讨其miRNA特异性表达,对新生儿HIE诊断和预后判断的意义,旨在为该病的相关诊治研究提供参考。

MicroRNA (miRNA) is a kind of highly conserved endogenous single stranded small molecule RNA. miRNA regulate gene expression by selective binding mRNA. Recent research shows that central nervous system includes a number of miRNA, and miRNA participates in many pathophysiological processes, such as the growth and development of nerve cells, repair of tissue damage, tumorigenesis, neurodegeneration and so on. This article attempts to expound miRNA profile of neonatal hypoxic-ischemia encephalopathy (HIE), and to explore the significance of miRNA-specific expression in the diagnosis and prognosis of neonatal HIE, in order to put forward new research ideas and methods for diagnosis and treatment of neonatal HIE.