早期血液灌流联合盐酸戊乙奎醚治疗急性有机磷农药中毒患者的临床效果

Clinical effect of early hemoperfusion combined with penehyclidine in patients with acute organophosphorus pesticide poisoning

目的分析早期血液灌流(HP)联合盐酸戊乙奎醚(PHCD)治疗急性有机磷农药中毒(AOPP)的临床效果。方法回顾性分析我院2016年1月至2019年1月收治的50例AOPP患者的临床资料,按治疗方式的不同将其分为对照组(25例,常规治疗+HP)和观察组(25例,常规治疗+HP+PHCD)。比较两组的临床疗效、炎症、心肌损伤指标。结果观察组的治疗总有效率显著高于对照组(P<0.05)。治疗后,两组患者的AchE、FT3水平均升高,NLR、TNF-α、h-FABP、α-HBD水平均降低,且观察组优于对照组(P<0.05)。结论早期HP联合PHCD治疗AOPP的临床效果显著,能有效阻断炎症反应,减少心肌损伤。

Objective To analyze the clinical effect of early hemoperfusion (HP) combined with penehyclidine (PHCD) in patients with acute organophosphorus pesticide poisoning (AOPP). Methods The clinical data of 50 patients with AOPP admitted in our hospital from January 2016 to January 2019 were retrospectively analyzed and divided into control group (25 cases, routine treatment + HP) and observation group (25 cases, routine treatment + HP + PHCD) according to different treatment methods. The clinical efficacy, the indexes of inflammation and myocardial injury were compared between the two groups. Results The total effective rate of treatment in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the levels of AchE and FT3 in both groups increased, TNF-α and the levels of TNF-α, h-FABP,α-HBD in both groups decreased, and those in the observation group were better than the control group (P<0.05). Conclusion Early HP combined with PHCD in the treatment of AOPP has a significant clinical effect. It can effectively block inflammation and reduce myocardial injury.