摘要
乙型肝炎病毒(HBV)属于嗜肝DNA病毒科正嗜肝DNA病毒属。HBV感染可引发急性和慢性肝炎,已成为全球性的健康问题。HBV衣壳装配调节剂可以对pgRNA衣壳化以及HBV DNA的合成等HBV复制的多个阶段发挥重要作用,因而成为乙肝药物研发的新热点。该文针对HBV衣壳蛋白装配调节剂研究进展进行综述。
Hepatitis B virus (HBV) belongs to the Hepadnaviridae family. HBV infection may lead to acute and chronic hepatitis, which has become a global health issue. HBV capsid protein assembly modulators play an important role in multiple stages of HBV replication, such as encapsidation of pgRNA and synthesis of HBV DNA, thus becoming a new hotspot in the research and development of hepatitis B drugs. This paper reviews the research progress of HBV capsid protein assembly modulators.
作者
杨璐
吴硕
李玉环
YANG Lu;WU Shuo;LI Yu-huan(Beijing Key Lab of Antimicrobial Agents, Institute of Medicinal Biotechnology,Key Lab of Antibiotic Bioengineering, Health Care Commission, Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2019年第11期1481-1487,共7页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81803592)
国家科技部“重大新药创制”科技重大专项(No 2018ZX09101003-003-003)
北京协和医学院“中央高校基本科研业务费”(No 332017076)
关键词
乙型肝炎病毒
衣壳组装
抗乙肝药物
衣壳装配调节剂
衣壳错配
空衣壳
hepatitis B virus
capsid assembly
anti-HBV drugs
capsid protein assembly modulators
aberrant capsid
empty capsid
