甲基苯丙胺与HIV-1Tat蛋白协同诱导神经细胞自噬的研究进展

Research process in synergistic induction of neuronal autophagy by methamphetamine and HIV-1Tat protein

甲基苯丙胺滥用与HIV感染是当今世界严重的公共卫生问题及社会问题。自噬是内质网衍生的囊泡包裹异常蛋白及细胞器,形成自噬小体,并转运至溶酶体降解的过程。甲基苯丙胺与HIV-1Tat蛋白均可诱导神经细胞自噬,该文综述近年来两者诱导神经细胞自噬的研究进展,并探讨两者与自噬的关系,为寻找有效的药物干预靶点提供参考。

Methamphetamine(METH) abuse and HIV infection are serious public health and social issues in the current world. Autophagy is a process in which vesicles derived from endoplasmic reticulum package abnormal proteins and damaged organelles to form autophagosomes and transport them to lysosomes for degradation. Both METH and HIV-1Tat protein can induce autophagy in nerve cells, therefore, in this review, the research process of neuronal autophagy induced by METH and HIV-1Tat protien were summarized, and the interaction of METH, HIV-1Tat protein, and autophagy were explored, so as to provide reference for searching for effective drug intervention targets.