麻痹活络汤联合氯吡格雷治疗后循环脑梗死31例

Treating 31 Cases of Posterior Circulation Cerebral Infarction with Mabi Huoluo Decoction and Clopidogrel

目的:观察麻痹活络汤联合氯吡格雷治疗后循环脑梗死的临床疗效。方法:将61例患者随机分为观察组31例和对照组30例,对照组使用氯吡格雷75 mg/次,1次/d进行治疗,观察组在对照组基础上加用麻痹活络汤治疗,2组分别于治疗前后测定血清基质金属蛋白酶9(MMP-9)、白细胞介素17(IL-17)、超敏C反应蛋白(hs-CRP)水平,评定治疗前后神经缺损评分(NIHSS)、日常生活活动能力评分(ADL)、依赖生存状态(BI)及残疾率(mRS)。结果:治疗结束后3个月内,Barthel指数、Rankin量表(mRS)评分2组比较差异有统计学意义(P<0.05)。血清MMP-9、IL-17、hs-CRP水平治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后2组组间比较差异也有统计学意义(P<0.05)。NIHSS及ADL评分治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后2组组间比较差异也有统计学意义(P<0.05)。结论:麻痹活络汤联合氯吡格雷治疗后循环脑梗死,可显著降低血清炎性因子水平,提高远期疗效。

Objective: To observe clinical effects of Mabi Huoluo decoction and clopidogrel in the treatment for posterior circulation cerebral infarction. Methods: All 61 patients were randomly allocated to the observation group(31 cases) and the control group(30 cases) randomly, the control group were treated with clopidogre, 75 mg each time, once each day and the observation group took Mabi Huoluo decoction on the foundation of Western medicine, to detect the levels of MMP-9, IL-17 and hs-CRP before and after treating, to assess national institute of health stroke scale(NIHSS), activity of daily living ability score(ADL), Barthel index(BI) and Rcmkin scale(mRS).Results: Within three months after treating, the difference showed statistical meaning in BZ and mRS scores between both groups(P<0.05). The difference was statistically significant in the levels of MMP-9, IL-17 and hs-CRP within two groups before and after treating(P<0.05);the difference could be found between both groups after treating(P<0.05).The difference could be found in NIHSS and ADL scores within two groups before and after treating(P<0.05), the difference was statistically significant between both groups after treating(P <0.05). Conclusion:Mabi Huoluo decoction and clopidogrel in the treatment for posterior circulation cerebral infarction could remarkably lower the levels of serum factors and lift long-term effects.