近20年高血压及靶器官损害风险因素研究趋势可视化分析

Visualization analysis on research trends of risk assessment of hypertension and target organ damage in recent two decades

目的分析近20年国内外高血压及靶器官损害风险因素相关研究的热点及发展趋势。方法计算机检索中国知网(CNKI)与Web of Science(WOS)中高血压及靶器官损害风险评估相关文献(起止时间为1999年1月1日至2018年4月15日),采用CiteSpace V、KNS6.6定量分析对研究者、研究机构、资助基金和关键词等进行可视化分析,探讨主要研究团体、核心引文、研究热点、前沿及发展趋势。结果近20年国内外高血压及靶器官损害风险评估研究呈逐年上升趋势;其中主要研究者有胡大一、吴寿岭、孙宁玲、张永红及吴兆苏,LIP GYH、Benjamin EJ、Devereux RB、Bohm M、Deev AD、Nasir K等;主要研究机构有北京大学人民医院、解放军总医院、阜外心血管病医院等及哈佛大学、加州大学、波士顿医疗保健系统、乔治霍普金斯大学、美国国立卫生研究院等;心血管风险与靶器官损害经典研究的主要危险因素有年龄、性别、血压、血脂异常、肥胖、吸烟和糖尿病等;近年已深入到对同型半胱氨酸、血压变异性与昼夜血压节律、左室肥厚、动脉僵硬度、动脉粥样斑块、血管弹性、肾功能损害等热点问题的关注。结论近20年来,高血压及靶器官损害风险评估逐渐成为热点,国内研究的深度及广度较国外仍有待提高;已明确的心血管风险与靶器官损害的生物学指标对构建具有中医特色的高血压及其靶器官损害风险评估指标体系与预警模型有启示意义。

Objective To analyze the hot spots and development trends of the relevant literature about risk assessment of hypertension and target organ damage in recent 20 years. Methods Computers were used to retrieve the risk assessment of hypertension and target organ damage in CNKI and WOS from January 1,1999 to April 15,2018.CiteSpaceV and KNS6.6 were used to visualize the authors,research institutes,fund and keywords,and discuss their major research groups,hot spots,core citations,research frontiers and trends,etc. Results The literature analysis showed that the main researchers were HU Da-yi,WU Shou-Ling,SUN Ning-Ling,ZHANG Yong-Hong and WU Zhao-Su,LIP GYH,BENJAMIN EJ,DEVEREUX RB,BOHM M,DEEV AD,NASIR K,etc.The main research institutions were Peking University People's Hospital,Chinese PLA General Hospital,Fuwai Hospital and Harvard University,University of California System,Boston Health Care System,Johns Hopkins University,NIH and so on.The major risk factors for cardiovascular risk and target organ damage were age,sex,blood pressure,TC,HDL-C,BMI,smoking and diabetes in classical research,and attention was paid to homocysteine,blood pressure variability,circadian rhythm of blood pressure,and left ventricular hypertrophy,arterial stiffness,atheromatous plaque,vascular elasticity,renal impairment and other hot issues in recent research. Conclusions In the past 20 years,the risk assessment of hypertension and target organ damage has gradually become a hot spot,the depth and breadth of domestic research is still to be improved.Cardiovascular risk and biological indicators of target organ damage are of great significance to establish the risk assessment index system and early warning model of hypertension and target organ damage with Chinese medicine.