阿司匹林片与阿托伐他汀钙片联合治疗急性脑梗死对神经功能与不良反应的影响

Effects of Aspirin Tablets Combined with Atorvastatin Calcium Tablets on Neurological Function and Adverse Reactions in Patients with Acute Cerebral Infarction

目的:探析阿司匹林与阿托伐他汀钙片联合治疗急性脑梗死对神经功能与不良反应的影响。方法:以2017年1月至2018年10月为时间段,选择我院急性脑梗死患者80例,将其随机分为2组,各40例。采用阿司匹林治疗对照组,基于此联合阿托伐他汀钙片治疗观察组。比较两组治疗前后神经功能缺损评估(NIHSS评分)、高敏C反应蛋白(Hs-CRP)水平等变化、疗效、不良反应以及生存质量(SF-36量表)。结果:在NIHSS评分、hs-CRP水平上,治疗前两组对比未表现出统计学差异,且P>0.05;而治疗后观察组上述指标较对照组均显著下降,且组间存在统计学差异,且P<0.05。在治疗总有效率上,对照组为75.0%,观察组为92.5%,二者存在统计学差异,且P<0.05。在不良反应上,对照组发生率7.5%,观察组为5.0%,二者存在统计学差异,且P<0.05。在生存质量评分上,两组在情感职能、社会、生理、躯体等功能评分上表现出统计学差异,且P<0.05。结论:阿司匹林与阿托伐他汀钙片联合治疗急性脑梗死的效果显著,即可有效减轻患者炎症,改善其神经功能,且安全性高,不良反应少,可提升患者生存质量,因此值得应用推广。

Objective: To investigate the effect of aspirin combined with atorvastatin calcium tablets on neurological function and adverse reactions in patients with acute cerebral infarction. Methods: From January 2017 to October 2018, 80 patients with acute cerebral infarction in our hospital were randomly divided into two groups, 40 in each group. The control group was treated with aspirin, and the observation group was treated with atorvastatin calcium tablets. The changes of NIHSS score (neurological deficit scale), Hs-CRP (high sensitive C-reactive protein) level, curative effect, adverse reactions and quality of life (SF-36 scale) were compared between the two groups before and after treatment. Results: At NIHSS score and hs-CRP level, there was no statistical difference between the two groups before treatment, and P>0.05. After treatment, the above indexes in the observation group decreased significantly compared with the control group, and there was statistical difference between the two groups, and P<0.05. The total effective rate of treatment was 75.0%in the control group and 92.5%in the observation group. There was a statistical difference between the two groups, and P<0.05. The incidence of adverse reactions was 7.5%in the control group and 5.0%in the observation group. There was a statistical difference between the two groups (P<0.05). On the quality of life score, there were significant differences in emotional function, social, physiological and physical function scores between the two groups, and P<0.05. Conclusion: The combination of aspirin and atorvastatin calcium tablets has a significant effect on acute cerebral infarction, which can effectively reduce inflammation and improve neurological function of patients with high safety and fewer adverse reactions, and can improve the quality of life of patients, so it is worthy of application and promotion.