HFHD与HD治疗在ESRD患者中的疗效及生存率比较

Comparison of the efficacy and survival rate of HFHD and HD in ESRD patients

目的:对比分析高通量血液透析(HFHD)与血液透析(HD)在终末期肾病(ESRD)中的临床疗效及其对心脏功能、生存率的影响。方法:回顾性分析120例ESRD患者的临床资料,将患者分为观察组(HFHD治疗)和对照组(HD治疗),每组各60例。比较两组患者治疗前后的血清尿素氮(BUN)、肌酐(SCr)、β2-微球蛋白(β2-MG)和全段甲状旁腺激素(iPTH)水平、心脏功能及生存率。结果:治疗后,观察组患者的血清中BUN、SCr、iPTH和β2-MG水平低于治疗前(P<0.05);对照组患者的血清BUN、SCr水平低于治疗前(P<0.05);治疗后,观察组的血清iPTH和β2-MG水平均低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的LVEF及E/A值高于对照组(P<0.05)。结论:HFHD治疗对ESRD患者血液内各毒素的清除能力较突出,同时可显著改善患者的心脏功能。

Objective:To compare and analyze the clinical efficacy of high flux hemodialysis(HFHD)and hemodialysis(HD)in patients with end-stage renal disease(ESRD)and their effects on cardiac function and survival rate.Methods:Clinical data of 120 patients with ESRD was retrospectively analyzed,and the patients were divided into observe group(HFHD training)and control group(HD therapy),60 cases in each group.The levels of serum urea nitrogen(BUN),creatinine(SCr),β2-microglobulin(β2-MG),total parathyroid hormone(iPTH),cardiac function and survival rate were compared between the two groups before and after treatment.Results:After treatment,the serum BUN,SCr,iPTH andβ2-MG levels in the observation group were lower than those before treatment(P<0.05),the serum BUN and SCr levels in the control group were lower than those before treatment(P<0.05),after treatment,the serum levels of iPTH andβ2-MG in the observation group were lower than those in the control group,with statistical significance(P<0.05).After treatment,the LEVEF and E/A values in the observation group were higher than those in the control group(P<0.05).Conclusion:HFHD treatment has a prominent ability to remove toxins in blood of ESRD patients,and can significantly improve the cardiac function of patients.