活血化瘀类中药在颈动脉粥样硬化临床治疗中的应用进展

Progress of Application of Traditional Chinese Medicine of Activating Blood and Dissolving Stasis in the Clinical Treatment of Carotid Atherosclerosis

随着我国人口老龄化进程的加快,预测从2020年到2040年,我国老年人口的数量将由2.4亿增长至到4亿,全国60岁以上的老年人口占比将达到30%。随之而来的颈动脉粥样硬化(CAS)的发病率也出现逐年升高的趋势。中华医学会(CMA)神经病学分会指出,老年患者发生CAS的概率明显增加,且CAS的发病率随年龄增长有升高的趋势,这一现象也逐渐受到心血管界的广泛关注。研究表明,CAS不仅增加老年人发生跌倒、摔伤、晕厥的风险,同时也增加了其发生心血管事件、卒中的风险。因此,CAS的正确治疗对改善患者生活质量及预后具有积极意义。然而由于目前活血化瘀类中药对于治疗CAS的疗效参差不齐,因此本文就CAS的定义、流行病学、发病机制、目前临床常用的活血化瘀类中药进行综述,旨在对防治CAS的临床研究做一总结。

With the acceleration of China’s population aging process,it is predicted that from 2020 to 2040,the number of elderly population in China will increase from 240 million to 400 million,and the proportion of elderly people over 60 years old will reach 30%.The incidence rate of carotid atherosclerosis(CAS)has also increased year by year.The Neurology Branch of Chinese Medical Association(CMA)pointed out that the probability of CAS in elderly patients was increased significantly and the incidence rate of CAS was increased with age,and this phenomenon has also been widely concerned by the cardiovascular community.Studies have shown that CAS not only increases the risk of falls,bruises and syncope in the elderly,but also increases the risk of cardiovascular events and strokes.Therefore,the correct treatment of CAS has positive significance for improving patients’quality of life and prognosis.However,due to the current efficacy of traditional Chinese medicine ofactivating blood and dissolving stasis is differentin the treatment of CAS,this paper reviews the definition,epidemiology and pathogenesis of CAS and current clinical use of traditional Chinese medicine ofactivating blood and dissolving stasis,so as to make a summary for the clinical study of prevention and treatment of CAS.