阿奇霉素序贯治疗小儿肺炎的疗效及对血清TNF-α、PCT水平的影响

Efficacy of Azithromycin Sequential Therapy on Infantile Pneumonia and Its Effects on Serum TNF-α and PCT Levels

目的:探讨阿奇霉素序贯治疗小儿肺炎的疗效及对外周血清肿瘤坏死因子α(TNF-α)、降钙素原(PCT)水平的影响。方法:选取2015年6月至2018年6月于我院儿科就诊的70例小儿肺炎患者,并并用随机数字法将其随机分为A组(阿奇霉素序贯治疗)、B组(头孢美唑钠治疗)各30例;记录和比较两组患者治疗前、后血清中白介素-6(IL-6)、TNF-α、PCT的水平,临床治疗效果以及出现的不良反应等。结果:A组治疗总有效率为88.57%,B组总有效率为68.57%,差异有统计学意义(P<0.05);A组治疗后血清IL-6、TNF-α、PCT水平低于B组,差异有统计学意义(P<0.05);两组不良反应率比较差异无统计学意义(P>0.05)。结论:阿奇霉素序贯治疗相比常规头孢美唑钠治疗小儿肺炎可显著减轻炎性反应程度,疗效确切。

Objective:To explore the efficacy of azithromycin sequential therapy on infantile pneumonia and its effects on serum peripheral blood tumor necrosis factorα(TNF-α)and PCT levels.Methods:70 patients with infantile pneumonia who were admitted to department of pediatrics of our hospital from June 2015 to June 2018 were selected and randomly divided into group A(azithromycin sequential therapy)and group B(cefameprazole sodium)according to the random number table method,with 30 cases in each group.The serum levels of interleukin-6(IL-6),TNF-αand procalcitonin(PCT)before and after treatment,clinical treatment effects and adverse reactions were recorded and compared between the two groups.Results:The total effective rate of treatment was 88.57%in group A and 68.57%in group B(P<0.05).After treatment,the levels of serum IL-6,TNF-αand PCT in group A were lower than those in group B(P<0.05).There was no difference in adverse reactions rate between the two groups(P>0.05).Conclusions:Azithromycin sequential therapy can significantly reduce the inflammatory response degree compared with conventional cefmetazole sodium in the treatment of infantile pneumonia,and it has exact efficacy.