沙库巴曲缬沙坦致不良反应的文献分析

Literature analysis of adverse drug reactions induced by sacubitril/valsartan

目的:了解沙库巴曲缬沙坦致不良反应发生的情况及特点,为临床安全用药提供参考。方法:检索有关沙库巴曲缬沙坦不良反应的相关文献,对患者的性别、年龄、原患疾病、药物使用情况及不良反应临床表现、处理、转归等数据进行汇总并统计分析。结果:沙库巴曲缬沙坦所致不良反应的个案报道共13例,均来自国外期刊。其中男性12例,女性1例,均为合并其他基础疾病的老年患者;不自主肌肉运动3例、心律失常6例、深度血管麻痹1例、T波过度敏感导致心悸1例、横纹肌溶解1例以及小肠肠梗阻1例;停药后症状好转12例,未好转1例;预后良好6例,预后较差7例。结论:使用沙库巴曲缬沙坦时应加强用药监测,警惕不良反应的发生,以便及时进行对症处理。

Objective: To investigate the characteristics of adverse drug reactions (ADRs) induced by sacubitril/valsartan in order to provide references for safety drug use. Methods: Literature about ADRs caused by sacubitril/valsartan was searched and summarized. The gender, age, original disease, drug use, clinical manifestation, treatment and outcome of the patients with those ADRs were analyzed statistically. Results: Thirteen cases were found which were published as case report in foreign journals. Among them, 12 cases were male and 1 case was female. All the patients were elderly patients with other co-existing diseases. There were 3 cases of involuntary muscle movement, 6 cases of arrhythmia, 1 case of serious vasoparalysis, 1 case of palpitations caused by over-sensitive T-wave, 1 case of rhabdomyolysis, and 1 case of small bowel obstruction. After withdrawal, 12 patients improved while 1 patient did not. The prognosis was good in 6 patients and poor in 7 patients. Conclusion: Physicians and pharmacists should pay more attentions to the safety monitoring of sacubitril/valsartan during medication and be alert to the occurrence of ADRs in order to deal with them in time.