CT血流灌注结合血脑屏障标志蛋白对中毒性休克患者神经元损伤中的评价作用

The efficacy of CT perfusion plus blood-brain barrier marker protein on neuronal injury in patients with toxic shock

目的:分析CT血流灌注结合血脑屏障标志蛋白对中毒性休克患者神经元损伤的评价价值。方法:选取院内妇产科门诊与住院中毒性休克患者60例及30例健康人员作为观察对象,中毒性休克患者分为轻度与重度两组,观察三组患者相关临床指标。结果:重度组CT灌注相关指标明显高于其他两组,轻度组明显高于对照组。重度组紧密连接蛋白相关指标表达水平明显除神经元特异性烯醇化酶(Neuron Specific Enolase,NSE)指标外均明显低于其他两组,轻度组除NSE指标外明显低于对照组。三组调查对象CT灌注相关指标及紧密连接蛋白表达均存在显著差异(P<0.05)。结论:中毒性休克患者多伴随神经损伤,而明确此病症临床指标变化规律对于诊治具有重要意义,本次调查证实,CT血流灌注结合血脑屏障标志蛋白能够为中毒性休克患者神经元损伤的发生及发展评估提供可靠的早期预测指标,同时为诊治提供新靶点。

Objective: To evaluate the effect of CT perfusion plus blood-brain barrier marker protein on neuronal injury in patients with toxic shock. Methods: 60 patients with toxic shock in and 30 healthy people were selected as objects. The patients with toxic shock were divided into mild and severe group. The clinical indexes in the three groups were observed. Results: The relative indexes of CT perfusion in the severe group were significantly higher than the other two groups, and those in the mild group were significantly higher than the control group. The expression level of the related indexes of tight junction protein in the severe group was significantly lower than the other two groups except the NSE index. The level of NSE in mild group was significantly lower than the control group. There were significant differences in CT perfusion parameters and tight junction protein expression among the three groups (P<0.05). Conclusion: Most of the patients with toxic shock are accompanied by nerve injury, and it is important to make clear the changes of clinical indexes in the diagnosis and treatment of the disease. CT perfusion combined with blood-brain barrier marker protein can provide a reliable early predictor for the occurrence and development of neuronal injury in patients with toxic shock and provide a new target for diagnosis and treatment.