炎性肌病相关肺间质病变及血清学生物标志物的特征分析

Inflammatory myopathy associated pulmonary interstitial lesions and serological biomarker characteristics analysis

目的:探讨炎性肌病(IM)相关肺间质病变(ILD)及血清学生物标志物的特征。方法:以2015年10月-2018年10月间进入医院治疗的43例IM并发ILD患者为A组研究主体。以同期进入该院治疗的43例IM未并发ILD患者为B组研究主体。对其进行血清生物标志物和肺功能检测,对比其临床特征。结果:A组患者的肺功能指标均低于B组,差异有统计学意义(P<0.05)。A组患者的KL-6(Ⅱ型肺泡细胞表面抗原)水平高于B组(P<0.05)。其他血清学生物标志物数值与B组对比差异无统计学意义(P>0.05)。结论:血清学生物标志物可作为IM合并ILD的评估指标,其能够反映患者的病情程度,具有检测价值。

Objective:To analysis the inflammatory myopathies(IM)related interstitial lung disease(ILD)and serological characteristics of biomarkers.Methods:In October 2015-2018,10 months into the hospital for treatment of 43 patients with IM concurrent ILD for group A research subject.In the same period in our hospital treatment of 43 patients with IM not concurrent ILD subject for the research of group B.On the serum biomarkers and pulmonary function testing,comparing their clinical features.Results:the lung function of the group A were lower than group B,there are differences in contrast group(P<0.05).Group A KL-6(Ⅱalveolar cell surface antigen)levels higher than group B(P<0.05).Other serological biomarkers numerical no difference compared with group B(P>0.05).Conclusion:the serological biomarkers can be used as IM merge ILD evaluation index,it can reflect the extent to which the patient,with test value.