pH敏感性生物医用材料在药物传递中的研究与进展

Research and Progress of pH-sensitive Biomedical Materials in Drug Delivery

目的:概述几类常见的pH敏感性生物医用材料在药物传递中的研究与进展,为其在后续pH敏感性生物材料的研究与开发提供参考。方法:通过文献研究,总结归纳常见的四类pH敏感性生物材料的作用机理和在药物传递中的应用,探讨其在临床转化上存在的挑战与研究方向。结果与结论:pH敏感性生物医用材料可根据人体内不同组织器官环境的酸碱性来使药物到达并作用于病灶部位,达到治疗的效果。但其在产品的研究与开发中还存在很多问题,而面临最大的挑战即是选择、修饰以及整合相应材料,设计并制备出安全有效的pH敏感性生物医用材料。解决因不同生物材料结构特点而产生的技术难题,才能实现真正的产品化和临床化。

Objective: The research and progress of several common pH-sensitive biomedical materials in drug delivery were summarized in order to provide references for subsequent research and development of pHsensitive biomaterials in the future. Methods: Through literature review, the effective mechanism of four types of pH-sensitive biomaterials and their application in drug delivery were summarized. The challenges and research directions in clinical translation were discussed. Results and Conclusion: pH-sensitive biomedical materials can make the drug reach and act on the lesion sites according to the acidity and alkalinity of different tissues and organs in the body, thereby achieving therapeutic effect. But, there were still many problems in the research and development of the products, and the biggest challenge is how to select, modify and integrate the corresponding materials to design and produce safe and effective pH-sensitive biomedical materials. The technical problems caused by the different structural characteristics of biomaterials needed to be solved so as to realize the real productization and clinical application.