抗C反应蛋白自体抗体在系统性红斑狼疮中的研究进展

Advances in Autoantibodies against C-reactive Protein in Systemic Lupus Erythematosus

系统性红斑狼疮(SLE)是一种可累及多脏器系统的慢性自身免疫性疾病,其发病机制尚不明确。有研究表明,免疫炎症反应和细胞凋亡清除受损是SLE发生发展的关键事件,在此过程中,五聚蛋白家族发挥重要作用。本文总结了抗C反应蛋白自体抗体与SLE疾病的相关性研究进展。

Systemic lupus erythematosus(SLE)is a chronic autoimmune disease that involves multiple organs and tissues.Its pathogenic mechanism remains unclear.Impaired inflammatory response and reduced clearance of immune cells are key events in the development of SLE,during which the pentraxin family plays an important role.This article summarizes recent advances in the relationship between anti-C-reactive protein autoantibody and SLE.