富亮氨酸胶质瘤失活1蛋白自身抗体相关性脑炎二例

Leucine-rich Glioma-inactivated Protein 1 Antibody-associated Encephalitis:Report of Two Cases

富亮氨酸胶质瘤失活1蛋白(LGI1)抗体脑炎是一种由LGI1抗体参与的自身免疫性脑疾病,多见于中老年人,临床表现常以精神行为异常、面臂肌张力障碍发作、低钠低钾血症为主,经过丙种球蛋白和/或激素等治疗有效。济南市人民医院神经内科于2018年1月至10月诊治了2例LGT1抗体脑炎,表现为精神行为异常、癫痫发作、低钠血症或低钾血症,经免疫球蛋白和激素治疗后病情好转。

Leucine-rich glioma-inactivated protein 1(LGI1)antibody-associated encephalitis is an autoimmune brain disease mainly seen in mid-aged and elderly people.Its main clinical manifestations include abnormal mental behaviors,facial-arm dystonia,hyponatremia,and hypokalemia.Immunotherapy with gamma globulin and/or hormone is effective.Two patients with LGT1 antibody-associated encephalitis were diagnosed in our center between January 2018 and October 2018,with typical clinical findings.The disease was cursed after immunoglobulin and hormone treatments.