云南汉族、彝族躯体攻击行为与MAOA μ-VNTR多态性的关联性分析

Correlation Analysis between the Physical Aggression Behavior of Yunnan Han and Yi Nationalities and MAOA μ-VNTR Polymorphism

目的 探讨云南汉族、彝族人群躯体攻击行为(aggressive behavior,AB)与单胺氧化酶A基因(Monoamine oxidase-A,MAO-A)启动子区域30bp-VNTR(MAOAμ-VNTR)多态性的关联性,以及其与文化程度、婚姻状况、吸烟、饮酒4个潜在风险因素之间是否存在交互作用。方法 对495例男性躯体攻击行为者和527例男性健康对照,应用荧光标记引物结合毛细管电泳分型技术进行MAOAμ-VNTR基因分型。运用SPSS软件进行数据统计。结果 云南汉族、彝族群体的MAOAμ-VNTR多态性与躯体攻击行为无直接相关性(P>0.05),且与4个潜在风险因素之间不存在交互作用;躯体攻击行为的风险因素为有无吸烟史以及低文化程度(P=0.001)。结论 云南汉族、彝族群体的MAOAμ-VNTR多态性与躯体攻击行为不存在相关性;两个群体的躯体攻击行为发生的风险因素为低文化程度和吸烟史。

Objective To analyse the genetic relationship between MAOA μ-VNTR polymorphism and physical aggressive behavior(AB) in Yunnan Han and Yi populations and to test whether there are gene-risk factors interactions in MAOA μ-VNTR polymorphism and degrees of education, marital status, drinking and smoking. Methods Health controls were made between 495 male with AB and another 527 males, MAOA μ-VNTR genotyping was performed using fluorescent-labeled primers combined with capillary electrophoresis typing. Data statistics were performed using SPSS software. Results MAOA μ-VNTR polymorphism has no direct correlation with AB and has no interaction with the four potential risk factors. The risk factors for AB are the history of smoking and low levels of education. Conclusion There was no correlation between MAOA μ-VNTR polymorphism and physical aggression behavior in Yunnan Han and Yi nationalities;the low education levels and smoking history of the two groups are risk factors for physical aggression behavior.