胃食管反流病患者精神心理因素、生活质量、睡眠质量的分析以及联用黛力新治疗的疗效观察

Analysis of mental and psychological factors,quality of life,sleep quality in patients with gastroesophageal reflux disease and the efficacy of combined treatment with Deanxit

目的 探讨胃食管反流病患者精神心理因素、生活质量、睡眠质量变化,以及在常规治疗基础上联用黛力新治疗的效果评价。方法纳入80例胃食管反流病(GERD)患者及80例同期在淮南东方医院集团总院体检健康者,分别采用Zung焦虑自评量表(SAS)和Zung抑郁自评量表(SDS)、中文版SF-36健康调查表、匹兹堡睡眠质量指数量表(PSQI)对研究对象精神心理状态、生活质量、睡眠质量进行评估。将GERD患者随机分为观常规组及观察组,常规组患者给予常规药物(艾司奥美拉唑+莫沙比利)治疗,观察组患者在常规药物治疗基础上联用黛力新。采用胃食管反流病问卷(GERD-Q)评分、SAS、SDS、SF-36、PSQI对两组患者治疗前后的症状、精神心理状态、生活质量、睡眠质量行评估。结果与健康者相比,GERD患者的SAS、SDS、PSQI评分增高,SF-36评分降低,差异均有统计学意义(P<0.01)。GERD患者生活质量评分与焦虑、抑郁评分呈负相关;睡眠质量评分与焦虑、抑郁评分正相关。观察组临床疗效显著优于常规组(P<0.01)。常规组治疗前后SAS、SDS、生活质量评分及睡眠质量评分无明显变化(P均>0.05);观察组治疗后SAS评分及SDS评分降低,生活质量评分增高,睡眠质量评分降低,差异均有统计学意义(P<0.05)。结论 GERD患者具有精神心理障碍及生活质量、睡眠质量下降的表现。在常规治疗基础上加用黛力新可有效改善GERD患者症状、心理状态及生活、睡眠质量。

Objective To explore changes of psychological factors, quality of life and quality of sleep in patients with gastroesophageal reflux disease, and to evaluate the effect of combination therapy with Deanxit on the basis of conventional therapy. Methods 80 cases of gastroesophageal reflux disease (GERD) and 80 check-up healthy people in the same period in our hospital were enrolled. Zung self-rating anxiety scale (SAS) and Zung self-rating depression scale (SDS), Chinese version of SF - 36 health survey, Pittsburgh sleep quality index scale (PSQI) were used to study the mental state, and to evaluate the quality of life and sleep. GERD patients were randomly divided into routine group and observation group. Patients in routine group were given routine drug (Esomeprazole + Mosapride), and patients in observation group were treated with Deanxit on the basis of routine drug treatment. After 8 weeks' treatment, gastroesophageal reflux disease questionnaire (GERD-Q), SAS, SDS, SF-36 and PSQI were used to evaluate symptoms, mental state, and quality of life and sleep quality of patients in two groups before and after treatment. Results Compared with healthy people in the control group, scores of SAS, SDS and PSQI in GERD group increased, and SF-36 score decreased. The difference was statistically significant ( P <0.01). The life quality score of GERD patients was negatively correlated with anxiety and depression scores, while sleep quality score was positively correlated with anxiety and depression scores. The clinical effect of the observation group was significantly better than that of routine group ( P <0.01). Before and after treatment, there were no significant changes in SAS, SDS, quality of life score and sleep quality score in routine group;while in observation group, SAS score and SDS score decreased, quality of life score increased, and sleep quality score decreased, with statistically significant differences ( P <0.05). Conclusion GERD patients have mental disorders, and poor quality of life and sleep quality. On the basis of routine treatment, Deanxit can effectively improve the symptoms, psychological status, and quality of life and sleep quality.