艾司奥美拉唑对急性上消化道出血的疗效观察

Observation of the Therapeutic Effect of Esomeprazole on Acute Upper Gastrointestinal Hemorrhage

目的探讨静脉滴注艾司美拉唑对急性上消化道大出血的疗效。方法收集急性上消化道大出血病例90例,随机分为3组,治疗一组(艾速平),治疗二组(耐信),对照组(泮托拉唑),在常规治疗的基础上,分别给予静点国产艾司奥美拉唑(艾速平),进口艾司奥美拉唑(耐信)和泮托拉唑治疗,观察其治疗效果,评估住院时间及住院费用等。结果治疗组和对照组治疗第3天呕血次数、黑便次数及出血量均较第1天明显减少,差异有统计学意义(P<0. 05)。治疗一组与治疗二组治疗1、3 d出血量均明显减少,差异无统计学意义(P>0. 05)。治疗组与对照组比较住院时间明显缩短,差异有统计学意义(P<0. 05)。治疗一组与治疗二组治疗住院时间比较,差异无统计学意义(P>0. 05)。治疗组与对照组比较日均费用明显增加,差异有统计学意义(P<0. 05),但治疗一组比治疗二组费用明显减少,差异有统计学意义(P<0. 05)。艾司奥美拉唑治疗急性上消化道出血24 h总止血率为71. 1%。治疗一组24 h止血率为76. 7%,治疗二组24 h止血率为90. 0%。两组比较其结果差异无显著性(P>0. 05)。对照组泮托拉唑治疗急性上消化道出血24 h总止血率为46. 7%。与治疗组比较其结果差异有显著性(P<0. 05)。结论艾司奥美拉唑对急性上消化道出血具有良好的治疗效果,其中国产艾速平与进口耐信的疗效相当,无统计学差异。艾速平的住院费用低于耐信,具有价格优势。

Objective To investigate the therapeutic effect of intravenous drip infusion of esmeprazole in the treatment of acute upper gastrointestinal hemorrhage. Methods 90 cases of acute upper gastrointestinal hemorrhage were randomly divided into three groups:treatment group one( Domestic esomeprazole),treatment group two( Imported esomeprazole),and control group( pantoprazole). The patients were treated with domestic esomeprazole( Aziapine),imported esomeprazole( Nexin) and pantoprazole respectively on the basis of routine treatment. The therapeutic effect was observed,and the hospitalization time and cost were evaluated. Results In the treatment group and the control group,the number of hematemesis,the number of black stool and the amount of blood loss on the third day were significantly lower than those on the 1 st day( P <0. 05). The amount of bleeding in the treatment group one and the treatment group two decreased significantly on the 1 st day and 3 rdday of treatment,with no significant difference between the two groups( P>0. 05). The hospitalization time in the treatment group was significantly shorter than that in the control group,with no significant difference between treatment group one and treatment group two( P>0. 05). Compared with the control group,the daily average cost of the treatment group increased significantly,and the difference was statistically significant( P<0. 05). The cost of treatment group one was significantly lower than that of treatment group two( P<0. 05). The total 24-hour hemostatic rate of esomeprazole in the treatment of acute upper gastrointestinal hemorrhage was 71. 1%. The hemostatic rate was 76. 7% in treatment group one and 90. 0% in treatment group two. There was no significant difference between the two groups( P>0. 05). In the control group,the total hemostatic rate was 46. 7% for 24 hours in the treatment of acute upper gastrointestinal hemorrhage. There was significant difference between the treatment group and the control group( P<0. 05). Conclusion Esomeprazole has a good therapeutic effect on acute upper gastrointestinal hemorrhage. The effects of domestic and imported esomeprazole are similar and there are no statistical differences in the two groups. Hospitalization cost of domestic esomeprazole is lower than that of imported esomeprazole,thus Aziapine has the price advantage.