期刊文献+

泛素-蛋白酶体系统在视网膜病变中的作用及其机制 被引量:2

Effects of ubiqutin-proteasome system in retinopathy and their mechanism
下载PDF
导出
摘要 泛素-蛋白酶体系统是真核细胞内重要的蛋白质降解系统,参与调节细胞周期、基因转录、抗原递呈、细胞增生与分化以及信号转导等各种病理生理过程.泛素-蛋白酶体功能异常与肿瘤、神经退行性疾病、心血管疾病等多种疾病致病机制相关.近年来,越来越多的研究也证实泛素-蛋白酶体系统存在于视网膜中,一些视网膜损伤在退行性疾病人群中同步出现.泛素-蛋白酶体系统参与视网膜氧化应激、炎症反应、血管新生、神经损伤、信号转导等病理生理过程.在糖尿病视网膜病变、年龄相关性黄斑变性、视网膜色素变性等疾病的发生和发展过程中,核因子κB(NF-κB)、转化生长因子-β(TGF-β)、活性氧簇(ROS)等一些信号通路起重要作用,其蛋白质的降解和合成失衡对视网膜疾病的病理生理过程产生重大影响.应用蛋白酶体抑制剂可以减轻网膜病变炎症等病理改变.本文对泛素-蛋白酶体系统在视网膜病变中的作用及机制进行综述. Ubiquitin-proteasome system (UPS) is the important protein degradation system in eukaryotic cells, participates in cell cycle, gene transcription, antigen-presenting, cell proliferation and differentiation, signal transduction and many other physiological processes.UPS dysfunction relates to pathogenic mechanisms in a variety of diseases such as cancer, neurodegenerative diseases and cardiovascular disease.In recent years, more and more researches confirmed that UPS exists in the retina, some retinal damage appeared in patients with neurodegenerative conditions.UPS is involved in the pathogenesis of diabetic retinopathy, age-related macular degeneration, macular pigment degeneration and other retinal diseases by regulating retinal oxidative stress, inflammation, angiogenesis, nerve damage, signal transduction and so on.Some signaling pathways, such as nuclear factor κB (NF-κB), transforming growth factor-β(TGF-β) and reactive oxygen species (ROS) play an important role.Their proteins degradation and synthesis of imbalances have a significant impact on the pathophysiological process of retinal diseases.Proteasome inhibitors can reduce inflammation pathological changes in retinal lesions.This review focused on the research progress of UPS in the development of retinopathy.
作者 王帅(综述) 刘升强(审校) Wang Shuai;Liu Shengqiang(Department of Ophthalmology,The Second Hospital of Dalian Medical University,Dalian 116027,China)
出处 《中华实验眼科杂志》 CAS CSCD 北大核心 2019年第10期843-848,共6页 Chinese Journal Of Experimental Ophthalmology
基金 辽宁省自然科学基金项目(20180550740).
关键词 泛素-蛋白酶体系统 糖尿病视网膜病变 年龄相关性黄斑变性 视网膜色素变性 病理生理机制 Ubiquitin-proteasome system Diabetic retinopathy Age-related macular degeneration Macular pigment degeneration Physiopathologic mechanism
  • 相关文献

参考文献2

二级参考文献38

  • 1吕红彬,袁援生,李燕,李俊.鼠青光眼模型视网膜神经节细胞中热休克蛋白27表达的研究[J].中华眼科杂志,2005,41(6):533-539. 被引量:16
  • 2叶健华,林晓峰,马承红,周斌兵,林文雄,钟亮尹,周昭远,严励.转化生长因子β_1在非增殖型糖尿病视网膜病变中的变化[J].眼科学报,2006,22(1):14-16. 被引量:7
  • 3Voorhees PM,Dees EC,0 ’ Neil B,Orlowski RZ. The proteasomeas a target for cancer therapy [ J]. Clin Cancer Res, 2003, 9(17) :6316-6325.
  • 4Kern TS. Contributions of inflammatory processes to the devel-opment of the early stages of diabetic retinopathy[ J]. Exp Dia-betes ifes,2007,2007:95103.
  • 5Hammes HP. Pericytes and the pathogenesis of diabetic retinop-athy[ J]. Horrn Metab i?es,2005,37(Suppl 1) :39-43.
  • 6Adachi-Uehara N, Kato M, Nimura Y, Seki N,Ishihara A, Matsu-moto Eyet al. Up-regulation of genes for oxidative phosphoryla-tion and protein turnover in diabetic mouse retina[ J]. Exp Eyei2es,2006,83(4) :849-857.
  • 7Massague J,Chen YG. Controlling TGF-beta signaling [ J ]. GenesDev,2000,14(6) :627-644.
  • 8Reeves WB, Andreoli TE. Transforming growth factor beta con-tributes to progressive diabetic nephropathy [ J ]. Proc Natl AcadSci US A,2000,97 (14) :7667-7669.
  • 9Papetti M, Shiyath J, Riley KN, Herman IM. FGF-2 antagonizesthe TGF-betal -mediated induction of pericyte alpha-smoothmuscle actin expression : a role for myf-5 and Smad-mediatedsignaling pathways [ J ]. Invest Ophthalmol Vis Sci, 2003,44(11):4994-5005.
  • 10Saika S,Kono-Saika S,Tanaka T,Yamanaka 0,Ohmshi Y,SatoM,et al. Smad3 is required for dedifferentiation of retinal pig-ment epithelium following retinal detachment in mice[ J]. LabInvest,2004M(10) : 1245-1258.

共引文献4

同被引文献15

引证文献2

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部