原发性高血压患者睡眠质量与脂质代谢的相关性研究

Study on the relationship between sleeping quality and lipid metabolism in patients with essential hypertension

目的:应用心肺耦合测评分析技术(CPC)探讨高血压患者脂质代谢与客观睡眠质量的关系。方法:纳入原发性高血压患者69例,应用CPC采集受试者睡眠质量数据,静脉血检测各项血脂水平,运用皮尔森相关性分析及多元回归分析统计睡眠质量与血脂水平的相关性。结果:原发性高血压患者的高密度脂蛋白水平与夜间熟睡时长呈正相关(P<0.05),与性别、浅睡时长呈负相关(均P<0.05);进一步多元回归分析显示,原发性高血压患者高密度脂蛋白水平与性别(β=-0.350,P=0.001)及熟睡时长相关(β=0.067,P=0.022)。结论:原发性高血压患者的睡眠质量与血脂代谢具有一定相关性,性别和夜间熟睡时长是高血压患者高密度脂蛋白的影响因素。

Objective:To investigate the relationship between lipid metabolism and objective sleep quality in patients with hypertension.Methods:Sixty-nine patients with hypertension were enrolled in this study.Sleep quality data,blood lipids and general data of the subjects were collected,and the relationship between cholesterol,high density lipoprotein,low density lipoproteintriglyceride and sleep quality data were analyzed by correlation analysis and multiple regression analysis.Results:In patients with hypertension,high density lipoprotein was positively correlated with the length of deep sleep(P<0.05),and negatively correlated with the length of light sleep(P <0.05).Multiple regression analysis showed that there were correlations between high density lipoprotein metabolism and gender (β=-0.350,P=0.001),deep sleep time (β=0.067,P=0.022).Conclusion:Gender and sleep can affect lipid metabolism in patients with hypertension.Men and the length of sleep are the influencing factors of high density lipoprotein metabolism in patients with hypertension.