小麦纤维素联合聚乙二醇对老年患者功能性便秘的疗效及炎症因子影响

Effect of Wheat cellulose combined with polyethylene glycol on functional constipation and inflammatory factors in elderly patients

目的:探讨小麦纤维素联合聚乙二醇治疗老年功能性便秘患者的临床效果以及对患者体内炎症因子产生的影响作用。方法:将功能性便秘老年患者86例作为研究对象,随机分为两组各43例,研究组患者给予小麦纤维素联合聚乙二醇进行治疗,对照组患者仅使用聚乙二醇进行治疗,观察两组患者的临床疗效和炎症因子水平变化情况。结果:研究组治疗后临床总有效率为95.35%,明显高于对照组76.74%,组间比较差异具有统计学意义(P<0.05);治疗前两组患者C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)各炎症因子水平比较差异无统计学意义(P>0.05),治疗后两组患者各项指标均明显降低,其中研究组降低程度明显优于对照组,组间比较差异具有统计学意义(P<0.05);研究组患者皮疹、腹部不适、恶心、心悸、头晕头痛、口干等不良并发症发生率为4.65%,明显少于对照组25.58%,组间差异具有统计学意义(P<0.05)。结论:小麦纤维素联合聚乙二醇治疗老年功能性便秘患者临床效果显著,改善患者炎性反应,安全性高,可推广使用。

Objective:To investigate the clinical effects of wheat cellulose combined with polyethylene glycol in the treatment of elderly patients with functional constipation and its effect on the production of inflammatory factors in patients.Methods:86 elderly patients with functional constipation admitted to our hospital from October 2016 to October 2018 were randomly divided into two groups.The study group was given wheat cellulose combined with polyethylene glycol.For the treatment,the control group was treated with only polyethylene glycol,and the clinical efficacy and inflammatory factor levels of the two groups were observed.Results:The total effective rate of the study group was 95.35%after treatment,which was significantly higher than that of the control group(76.74%).The difference between the two groups was statistically significant(P<0.05).The two groups of patients had CRP,TNF-αand IL-6 before treatment.There was no significant difference in the levels of inflammatory factors(P>0.05).After treatment,the indexes of the two groups were significantly lower.The reduction of the study group was significantly better than that of the control group.The difference between the two groups was statistically significant(P<0.05).The incidence of adverse complication such as rash,abdominal discomfort,nausea,palpitations,dizziness,headache and dry mouth in the study group was 4.65%,which was significantly lower than that in the control group(25.58%).The difference between the two groups was statistically significant(P<0.05).Conclusion:Wheat cellulose combined with polyethylene glycol in the treatment of elderly patients with functional constipation has a significant clinical effect,improve patients with inflammatory response,high safety,and can be promoted.