期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

神经干细胞的研究进展 被引量：1

The Development of Neural Stem Cells
下载PDF
导出
摘要 近年来的研究表明胚胎期和成年期动物的神经组织及人脑中可以分离出神经干细胞。神经干细胞具有增殖并分化成神经元及神经胶质细胞的潜能。本文综述了神经干细胞的分布、生物学特性、识别及其在治疗中枢神经系统疾病中的应用前景。 Recently,a rush of papers have showed that neural stem cells be isolated not only in the embryonic nervous system but also in the adult nervous system.Neural stem cells have some capacity for self-renewal,and can differentiate into neurons and glia.In this paper,the distribution,the biology characteristic,the identification,and the prospect in therapy of neural stem cells are reviewed.
作者 方富贵 张丽霞 李福宝
机构地区 安徽农业大学畜牧水产学院
出处 《四川畜牧兽医》 2002年第11期28-29,31,共3页 Sichuan Animal & Veterinary Sciences
关键词 神经干细胞 生长因子 移植 生物学特性 neural stem cell growth factor implantation
分类号 Q813.1 [生物学—生物工程]
  • 相关文献

参考文献15

  • 1Reynolds BA et al. A Multipotent EGF-responsive Striatal Embryonic Progenitor Cell Produces Neurons and Astrocytes[J].J. Neurosci.,1992,12:4565-4574
  • 2Sally Temple. The development of neural stem cells[J]. Nature,2001,414:112- 117.
  • 3Reynolds BA et al. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system[J]. Science, 1992,255:1707-1710.
  • 4Gage FH et al. Mammalian neural stem cells[J]. Science, 2000,287:1433-1438.
  • 5Irving L Weissman. Stem cells: Units of Development, Units of Regeneration, and units in Evolution[J]. Cell,2000,100:157-168.
  • 6董艳,朱诚,江基尧.成年哺乳动物中枢神经系统干细胞[J].生理科学进展,2001,32(2):141-143. 被引量：3
  • 7Doetsch F et al. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain[J]. Cell, 1999,97:703-716.
  • 8Mckay R. Stem cells in the central nervous stem. Science, 1997,276:66-71
  • 9Weiss S, et al. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis[J]. J. Neurosci.,1996,16(23): 7599-7609.
  • 10Tropepe V,et al. Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon[J].Dev. Bio1.,1999,208:166- 188.

二级参考文献13

  • 1[1]Palmer TD, Markakis EA, Willhoite AR, et al. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci, 1999,19: 8487～8497.
  • 2[2]Ciccolini F, Svendsen CN. Fibroblast growth factor 2 (FGF-2) promotes acquisition of epidermal growth factor (EGF-2) responsiveness in mouse striatal precursor cells: identification of neural precursors responding to both EGF and FGF-2. J Neurosci,1998,18: 7869～7880.
  • 3[3]Craig CG, Tropepe V, Morshead CM, et al. In viw growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain. J Neu rosci, 1996, 16:2649～2658.
  • 4[4]Kuhn HG, Winkler J, Kempermann G, et al. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J Neu rosci, 1997,17: 5820～5829.
  • 5[5]Lim DA, Fishell GJ, Alvares-Buylla A. Postnatal mouse subventricular zone neuronal precursors can migrate and dif ferentiate within levels of the developing neuraxis. Proc Natl Acad Sci USA, 1997,94:14832～14836.
  • 6[6]Svendsen CN, Caldwell MA, Shen J, et al. Long-term sur vival of human central nervous system progenitor cells trans planted into a rat model of Parkinson' s disease. Exp Neu rol, 1997,148:135～146.
  • 7[7]Studer L, Tabar V, McKay RDG. Transplantation of ex panded mesencephalic precursors leads to recovery in parkin sonian rats. Nat Neurosci, 1998,1: 290～295.
  • 8[8]Jacques TS,Relvas JB,Nishimura S,et al. Neural precursor cell chain migration and civision are regulated through differ ent B1 integrins. Development, 1998,125: 3167～3177.
  • 9[9]Hohamsson CB, Momma S, Clarke DL, et al. Identifica tion of a neural stem cell in the adult mammalian central nervous system. Cell, 1999,96:25～34.
  • 10[10]Doetach F, Garcia-Verdugo JM, Alvarex-Buylla A. Re generation of a germinal layer in the adult mammalian brain. Proc Natl Acad Sci USA,1999,96:11619～11624.

共引文献8

同被引文献6

引证文献1

二级引证文献1

四川畜牧兽医
2002年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部