摘要
目的 比较切割球囊血管成形术(cutting bal-loon angioplasty,CBA)与普通球囊血管成形术(conventionalballoon angioplasty,BA)对血浆vWF和血清cTnI浓度的影响。方法 选择65例入院拟行冠脉介入治疗的不稳定型心绞痛(unstable angina pectoris,UAP)患者,随机分为两组,分别接受CBA或BA,球囊扩张后均放置支架。分别于术前、术后即刻、术后2h和6h抽取冠状静脉窦血样,测量血浆vWF的浓度;分别于术前、术后6h、24h和48h抽取肘静脉血样,测量血清cTnI的浓度。以上指标均以ELESCA双抗体夹心法进行测量。结果 两组患者靶病变情况无显著差异。CBA组的球囊最大充盈压明显低于BA组(P<0.01)。BA组术后即刻和2h的血浆vWF水平均明显高于A组(P<0.05)。BA组24h的血清cTnI水平明显高于A组(P<0.05)。结论 CBA以及联合支架植入术对UAP患者血浆vWF和血清cTnI浓度的影响均小于BA或其联合支架植入术,这可能是前者通过减少对血管内皮和心肌细胞的损伤,减少RS及心血管事件发生的机制之一。
Objectives To compare th effects between CBA and BA on plasma vWF and serum cTnl levels of unstable angina pectoris (UAP) patients. Methods A total of 65 UAP patients were randomly divided into two groups, respectively, accepted CBA or BA, and stents were planted in all patients after balloon angioplasty. Samples of coronary sinus blood were collected before angioplasty, immediate after as well as 2 h and 6 h after angioplasty to measure the content of vWF, and samples of veins blood also were collected before angioplasty, 6 h as well as 24 h and 48 h after angioplasty to measure the serum content of cTnl. The contents of vWF and cTnl were measured by ELESCA. Results There was no significant difference of the tar-
get lesions or the clinic characteristics between two groups. The maximum balloon filling pressure of group CBA was significantly lower than that of group BA (P <0.01). The plasma level of vWF in group BA was significantly ingher than that of CBA immediate and 2 h after angioplasty (P < 0.05). The serum level of cTnl in group BA was significantly ingher than that of group CBA at 24 h (P < 0.01). Conclusions The results suggest that CBA can significantly reduce the production of vWF and cTnl than that of BA. Tins may indicate that CBA and also plus stent implantation produce less injury of vessel wall and myocardial cell winch may account for the lower rate of restenosis and cardiovascular events of CBA.
出处
《岭南心血管病杂志》
2002年第5期314-317,共4页
South China Journal of Cardiovascular Diseases
