健康老年人血脂与甲状腺功能关系的研究

The relationship between thyroid hormone and blood lipid in the healthy elderly

目的 观察健康老年人补充小剂量甲状腺激素(TH)后血脂水平的变化。方法 从健康老年人中随机分为治疗组和对照组各60例。治疗组每日口服甲状腺片10mg,对照组每日口服Vit.B_130mg,连服6个月,所有受试者治疗前后均检测甲状腺功能指标包括高灵敏促甲状腺素(M-TSH)、游离三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)、总三碘甲状腺原氨酸(TT_3)、总甲状腺素(TT_4)、反T_3(rT_3)和血脂包括胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、载脂蛋白(apoA1)的水平并比较它们之间的关系。结果 服用甲状腺片后,治疗组TH水平有明显升高,TC、TG、LDL-C的水平也有不同程度的下降、HDL-C、apoA1的水平有轻度的升高。治疗组服药后与治疗组服药前及对照组服药前后比较有显著性差异(P<0.01)。结论 小剂量TH补充治疗可升高老年人血清TH水平和降低血脂水平,并可望有益于老年人高脂血症的治疗。

Objectives To observe the relationsinp between thyroid hormone level and blood lipid level in the healthy elderly with therapy of small dose TH. Methods A total of 120 old healthy persons were randomly divided into two groups: 60 persons as treatment group and the other 60 persons as control group. Each person in treatment group took thyroid tablet 10 mg daily continuously for six months winle in control group took Vit.Bj 30 mg daily instead of thyroid tablet. The level of M-TSH, FT3, FT4, TT4, rT3, TC, TG, LDL-C, HDL-C, apoAl were measured in two groups before and after receiving TH or Vit. BI treatment. Results In the treatment group, the level of TH increased obviously, and TC, TG, LDL-C levels decreased also to some extent winle HDL-C, apoAl levels increased slightly, winch was significant difference when comparing with control group and pre-treat-ment groups. Conclusions To use small dose of TH as supplement treatment can increase the TH level of old healthy persons and decrease their blood lipid level. It would be benefit for treating hyperlipidemia in the elderly.