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蛇毒血小板膜糖蛋白Ib结合蛋白研究进展

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摘要 血栓形成在动脉粥样硬化、急性心肌梗死及PTCA术后再狭窄等病理过程中起着重要作用.通过对血小板栓塞形成的机制研究表明:血浆中血管假性血友病因子(vWF)与血小板GPIb的相互作用在止血过程和血栓形成的早期阶段起着关键作用.vWF主要来源内皮和巨核细胞,作为分子桥介导血小板和内皮下胶原的粘附反应,与GIb结合位点位于vWF分子509~695残基之间A1重复区的二硫环上.
作者 王桂平
出处 《岭南心血管病杂志》 2002年第5期370-373,共4页 South China Journal of Cardiovascular Diseases
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  • 1Peng M, Lu W, Kirby EP, et al. A1boaggregin-B: a new platelet agonist that binds to platelet membrane glycoprotein Ib. Biochemistry, 1991, 30:11529~11536
  • 2Yoshida E, Fujimura Y, Miura S, et al. Alboaggregin-B and Botrocetin: two snake venom proteins with highly homologous amio acid sequences but totally distinct functions on vWF binding to platelets. Biochem Biophys Res Commun, 1993, 191(3): 1389~1392
  • 3Andrews RK, Kroll MH, Ward CM, et al. Binding of a novel 50-kilodalton alboaggregin from Trimeresurus albolabris and related viper venom proteins to the platelet membrane glycoprotein Ib-IX-V complex. Effect on platelet aggregation and glycoprotein Ib-mediated platelet activation. Biochemistry, 1996, 35(38): 12629~12639
  • 4Sakurai Y, Fujimura Y, Kokubo T, et al. The cDNA cloning and molecular characterization of a snake venom platelet glycoprotein Ib-binding protein, mamushigin, from Agkistrodon halys blomhoffii venom. ThrombHaemost, 1998, 79(6): 1199~1207.
  • 5Taniuchi Y, Kawasaki T, Fujimura Y,et al. Flavocetin-A and-B two high molecular mass glycoprotein Ib hinding protein with high athinity purified from trimeresurus flavoriridis venom inhibit platelet aggregation at high shear stress. Biochem et Biophys Acta,1995, 1244(2-3) :331~338
  • 6Fukuda K, Mizuno H, Ateda H, et al.Crystallization and preliminary x-ray studies of flavocetin-A, a platelet glycoprotein Ib-binding protein from the babu snake venom . Acta Crystallogr D Biol Crystallogr, 1999, 55(11): 1911~1913
  • 7Shin Y, Okuyama I, Hasegawa J, et al. Molecular cloning of glycoprotein Ib-binding protein , flavocetin-A,which inhibits platelet aggregation.Thromb Res, 2000, 99(3): 239-247.
  • 8Taniuchi Y, Kawasaki T, Fujimura Y,et al. The high molecular mass glycoprotein Ib binding protein flavocetin A induces only small platelet aggregates in vitro. Thromb Res, 2000, 97 (2):67~75.
  • 9Hang MC, Lin HK, Peng HC, et al.Antithrombotic effect of crotalin, a platelet membrane glycoprotein Ib antagonist from venon of crotalus atrox.Bood, 1998, 91:1582~1589
  • 10Peng M, Lu W, Beviglia L, et al.Echicetin: a snake venom protein that inhibits binding of yon Willebrand factor and alboaggregins to platelet glycoprotein Ib. Blood, 1993, 81(9) :2321~2328

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