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蛇毒血小板膜糖蛋白Ib结合蛋白研究进展

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摘要 血栓形成在动脉粥样硬化、急性心肌梗死及PTCA术后再狭窄等病理过程中起着重要作用.通过对血小板栓塞形成的机制研究表明:血浆中血管假性血友病因子(vWF)与血小板GPIb的相互作用在止血过程和血栓形成的早期阶段起着关键作用.vWF主要来源内皮和巨核细胞,作为分子桥介导血小板和内皮下胶原的粘附反应,与GIb结合位点位于vWF分子509～695残基之间A1重复区的二硫环上.
作者 王桂平
机构地区 广州医学院 广州蛇毒研究所
出处 《岭南心血管病杂志》 2002年第5期370-373,共4页 South China Journal of Cardiovascular Diseases
关键词 蛇毒 血小板膜糖蛋白Ib结合蛋白 研究进展
分类号 R392－33 [医药卫生—免疫学]
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岭南心血管病杂志
2002年 第5期

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