小剂量尿激酶加法安明在脑梗塞早期的应用

The application of low dose urokinase and fragmin for patients with early stage of cerebral infarction .

目的 :研究小剂量尿激酶和法安明在脑梗塞早期应用的临床疗效。方法 :将 10 8例脑梗塞患者分为三组 ,分别采用小剂量尿激酶治疗 (简称尿激酶组 ) ;小剂量尿激酶加法安明治疗 (简称联合组 ) ;传统疗法 (简称对照组 )。治疗前后采用欧洲卒中评分法进行神经功能评分。结果 :治疗前各组分数无显著性差异 ,治疗后联合组 >尿激酶组 >对照组 ,差异均有显著性。联合组的卒中继续进展及再梗塞发生率明显降低。结论 :小剂量尿激酶与法安明联用能有效阻止血栓进展 ,减少再梗塞 ,有利于神经功能恢复 ,疗效显著而无明显副作用。

Objective: To study the clinical effect of low dose urokinas and fragmin for patients with early stage of cerebral infarction .Method:108 patients with acute cerebral infarction were divided into three groups: urokinase group that were treated with low dose urokinase ;united group that were treated with low dose urokinase and fragmin;Comparative group that were treated by traditional therapy. The European Stroke Scale was adopted before and after treatment.Result:The scales of neural function was not significanthy different among three groups before treatment. After treatment the scales fo neural function for united group was higher than that of urokinase group and the scales of urokinase group was higher than that of control group.The differences were significantly . The incidence of both aggravation and reoccurance of infarction was significantly reduced in united group .Conclusion:The usage of low dose urodinase and fragmin might prevent infarction from aggravating and reoccuring, the clinical effect was raised greatly without obvious side effects. [