前列腺癌E和N型钙粘附素的表达及意义

Correlation and Significance of E-Cadherin and N-Cadherin Expression in Prostate Cancer

背景与目的:E-钙粘附素表达缺失与许多种癌密切相关,而最近在乳腺癌的研究中发现N-钙粘附素的反常表达在引起癌细胞的浸润及转移方面有着比E-钙粘附素缺失更为明显而直接的作用。本研究拟探讨前列腺癌中E和N-钙粘附素的表达与癌分级、分期及前列腺特异抗原(prostatespecificantigen,PSA)的关系。方法:采用免疫组织化学染色法检测56例前列腺癌标本E和N-钙粘附素的表达。结果:E-钙粘附素阳性表达24例(43%),阴性表达32例(57%);N-钙粘附素表达阴性18例(32%),阳性38例(68%),E-钙粘附素表达缺失或N-钙粘附素阳性表达与肿瘤恶性程度及分期呈正相关(P均<0.01);与血清总PSA(T-PSA)和游离PSA(F-PSA)无明显相关性,而与F-PSA/T-PSA比值呈正相关(P<0.01)。结论:E-钙粘附素和N-钙粘附素与前列腺癌的发生、发展明显相关,可以作为判断前列腺癌恶性程度及预后的指标。

Background & Objective: Decreased expression of E Cadherin correlated with many kinds of cancer,but inappropriate expression of N cadherin has been reported in breast cancer recently ,which has a more distinct and direct role in promoting cancer cell motility than E cadherin.The aim of this study was to investigate the correlation between E Cadherin and N Cadherin expression with the grade and stage of prostate cancer and their relationship with prostate specific antigen (PSA). Methods: E Cadherin and N Cadherin expression in 56 prostate cancer samples were determined by immunohistochemical staining. Results: Twenty four patients (43%) were positive and 32 patients (57%) were negative in E Cadherin expression. Eighteen patients (32%) were negative and 38 patients (68%) were positive in N Cadherin expression. E Cadherin and N Cadherin were significantly related to the grade and stage of cancer and the change of F/T ratio (free prostate specific antigen/total prostate specific antigen ratio). There was no significant relationship between Cadherin expression and total prostate specific antigen (tPSA) or free prostate specific antigen (fPSA). Conclusion: E Cadherin and N Cadherin abnomal expressions may serve as the indicators to malignant degree and prognosis of the prostate cancer.