结肠直肠癌组织中粘蛋白MUC1和MUC2的表达及临床意义

Expression of Mucin MUC1 and MUC2 in Colorectal Carcinoma and Their Clinical Significance

背景与目的:粘蛋白MUC1的表达上调或MUC2的表达下调可能参与了肿瘤的发生,而MUC1和MUC2的表达中国人结肠直肠癌发生发展的关系未见报道。本研究的目的是探讨结肠直肠癌组织中粘蛋白MUC1和MUC2的表达与不同的临床病理参数间的关系及其临床意义。方法:采用免疫组化方法检测126例结肠直肠癌和20例正常结肠直肠粘膜中粘蛋白MUC1和MUC2的表达。结果:20例正常结肠直肠粘膜中粘蛋白MUC1和MUC2的表达阳性率分别为0和100%,而126例结肠直肠癌中粘蛋白MUC1和MUC2的阳性表达率分别为42.1%和36.5%(P<0.01);结肠直肠癌中粘蛋白MUC1的表达与肿瘤的浸润深度、淋巴结转移和Dukes分期呈正相关(P<0.05),与肿瘤的分化程度呈负相关(P<0.05);粘蛋白MUC2在结肠直肠癌中的表达与肿瘤的浸润深度、淋巴结转移和Dukes分期密切相关(P<0.05),而与肿瘤的分化程度无关(P>0.05)。结论:粘蛋白MUC1表达上调或MUC2表达下调可能参与了结肠直肠癌的发生发展,检测结肠直肠癌中粘蛋白MUC1和MUC2的表达可间接反映肿瘤的预后。

Background and Objective: The up regulation of mucin MUC1 expression or down regulation of mucin MUC2 expression may be involved in carcinogenesis of some neoplasms, but there was few report about the relationship between mucin MUC1 and MUC2 expression and Chinese colorectal carcinoma. The aim of this study was to explore relationship between expression of mucin MUC1 and MUC2 in colorectal carcinoma and clinicopathological parameters and their clinical significance. Methods: The expression of mucin MUC1 and MUC2 in 126 cases of colorectal carcinoma were detected by S P immunohistochemical technique. Results: The positive expression rates of mucin MUC1 and MUC2 in normal colorectal mucosa were 0 and 100%, respectively, but the positive expression rates of mucin MUC1 and MUC2 in 126 cases of colorectal carcinoma were 42.1% and 36.5%, respectively (P< 0.01); the expression of mucin MUC1 was positive correlated to the depth of invasion, lymph node metastasis,and Dukes staging (P< 0.05), but negative correlated to the degree of differentiation (P< 0.05) ; mucin MUC2 expression was related to invasion, lymph node metastasis, and Dukes staging (P< 0.05), but unrelated to differentiation (P>0.05). Conclusions: The up regulation of mucin MUC1 expression or down regulation of mucin MUC2 expression may be involved in carcinogenesis and progression in colorectal carcinoma, and the detecting of mucin MUC1 and MUC2 may be predicting its prognosis in colorectal carcinoma.