179例老年Ⅰ、Ⅱ期宫颈癌的临床疗效分析

Analysis of Clinical Efficiency of Treatment for 179 Geriatric Women with StageⅠorⅡCervical Carcinoma

背景与目的:老年宫颈癌预后较差,治疗并发症较多。本文分析老年Ⅰ、Ⅱ期宫颈癌手术治疗与放射治疗的疗效,以探讨更合适的治疗方法。方法:回顾性分析179例Ⅰa～Ⅱb期老年宫颈癌的临床资料,其中134例行根治性手术治疗,并根据个体状况辅以适当的放疗和/或化疗;45例采用根治性放射治疗,并根据个体状况辅以适当的化疗。结果:手术组和放射治疗组的5年生存率分别为78.32%和49.08%(P=0.04)。手术组并发症发生率为47.01%(63/134),其中严重并发症导致死亡3例;放射治疗组并发症发生率为75.63%(34/45)。结论:Ⅰ、Ⅱ期老年宫颈癌患者宜采用手术治疗,并根据其个体状况采取不同的辅助治疗方式。

Background & Objective: Elderly women with cervical carcinoma have the features of poor prognosis and high incidence rate of complications. This study was designed to evaluate the prognostic impact of surgery versus radiotherapy in old women with stage I and stage II cervical carcinoma and seek suitable treatment for such patients. Methods: Clinical data of 179 elderly women with stage Ia to stage IIb cervical cancer were analyzed retrospectively. One hundred and thirty four cases underwent radical hysterectomy also received appropriate adjuvant radiotherapy and/or chemotherapy. Forty five cases underwent radiation therapy received appropriate adjuvant chemotherapy. Results: The 5 year survival rates of patients underwent surgery and radiotherapy were 78.32% and 49.08%(P=0.04), respectively. The incidence rate of complications of patients receiving surgery was 47.01%(63/134). Three patients died of complications after radical hysterectomy. The incidence rate of complications of patients underwent radiotherapy was 75.63%(34/45). Conclusion: Geriatric patients with stage I and stage II cervical carcinoma should receive operation if possible and should receive adjuvant treatments according to personal conditions.